Histamine H1 receptors are expressed in mouse and frog semicircular canal sensory epithelia
| Autor: | Giulia Gastaldi, Laura Botta, Umberto Laforenza, Paolo Valli, Paola Perin, Simona Tritto, Sergio Masetto, Stefano Valli, Valeria Zampini, G. Zucca |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Immunoblotting
Histamine H1 receptor Biology Mice chemistry.chemical_compound Histamine receptor Species Specificity otorhinolaryngologic diseases medicine Animals Receptors Histamine H3 Receptors Histamine H1 Receptor Vestibular system Semicircular canal Reverse Transcriptase Polymerase Chain Reaction General Neuroscience Hair Cells Ampulla Histaminergic Rana esculenta Semicircular Ducts Immunohistochemistry Cell biology Mice Inbred C57BL medicine.anatomical_structure Vestibular Diseases chemistry Vertigo sense organs Hair cell Neuroscience Histamine |
| Zdroj: | NeuroReport. 19:425-429 |
| ISSN: | 0959-4965 |
| DOI: | 10.1097/wnr.0b013e3282f76151 |
| Popis: | Histamine-related drugs are commonly used in the treatment of vertigo and related vestibular disorders. Their site and mechanism of action, however, are still poorly understood. To increase our knowledge of the histaminergic system in the vestibular organs, we have investigated the expression of H1 and H3 histamine receptors in the frog and mouse semicircular canal sensory epithelia. Analysis was performed by mRNA reverse transcriptase-PCR, immunoblotting and immunocytochemistry experiments. Our data show that both frog and mouse vestibular epithelia express H1 receptors. Conversely no clear evidence for H3 receptors expression was found. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|