Prevalence, diagnosis and treatment of lower genital neoplasia in women with human immunodeficiency virus infection
| Autor: | Arsenio Spinillo, Rita Zappatore, G. Barbarini, Secondo Guaschino, Patrizia Tenti, Carratta L, Anna Maccabruni |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
Pathology medicine.medical_treatment HIV Core Protein p24 Uterine Cervical Neoplasms Cryotherapy Cervix Uteri Cervical intraepithelial neoplasia Gastroenterology Epithelium Acquired immunodeficiency syndrome (AIDS) White blood cell Internal medicine Immunopathology Humans Medicine Papillomaviridae Acquired Immunodeficiency Syndrome Anus Diseases business.industry Standard treatment Nucleic Acid Hybridization virus diseases Obstetrics and Gynecology medicine.disease female genital diseases and pregnancy complications Tumor Virus Infections medicine.anatomical_structure Reproductive Medicine Condylomata Acuminata DNA Viral Cohort HIV-1 Female Vulvar Diseases Viral disease business |
| Zdroj: | European Journal of Obstetrics & Gynecology and Reproductive Biology. 43:235-241 |
| ISSN: | 0301-2115 |
| DOI: | 10.1016/0028-2243(92)90179-3 |
| Popis: | The prevalence of lower genital neoplasia and Human Papilloma-virus-related genital lesions were evaluated in a cohort of 75 women with Human Immunodeficiency Virus type 1 (HIV-1) infection at different stages of HIV disease. The overall rate of cervical intraepithelial neoplasia (CIN) in the group studied was 29.3% ( 22 75 ). Eight out of 10 high-grade CIN lesions contained ‘high-risk’ HPV-DNA 16 18 and/or 31/35/51 as demonstrated by ‘in situ’ hybridization with biotinylated probes. Vulvar and/or perianal condylomata were histologically diagnosed in 14 patients (18.7%); nine of these biopsies contained detectable HPV-DNA which was always related to HPV 6 11 . The rate of high-grade CIN in symptomatic HIV-infected patients was 28% ( 7 25 ) as compared to 6% ( 3 50 ) of the other cases (P = 0.022). CD4 lymphocyte counts, white blood cell counts, CD4 + CD8 + cell ratio and percentage of CD4+ lymphocytes were lower in patients with high-grade CIN in comparison to the patients with negative colposcopical and/or cytological examination. After adequate standard treatment (cryotherapy, electrocauterization, cold-knife conization) only one case of CIN 2 recurred during the 2 years of follow-up period. The prevalence of lower genital neoplasia and HPV-related lesions among HIV-infected women is high and seems to correlate with the severity of HIV disease. |
| Databáze: | OpenAIRE |
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