Cytotoxicity Assessment of Latex Urinary Catheters on Cultured Human Urothelial Cells

Autor:	Michel Le Guillou, Charles Baquey, F. Jacob, Jean Louis Pariente, Laurence Bordenave, Reine Bareille
Rok vydání:	2000
Předmět:	Pathology medicine.medical_specialty business.industry Urology Urinary system Urine Epithelium medicine.anatomical_structure Cell culture Toxicity medicine Humans Rubber Urothelium Urinary Catheterization business Cytotoxicity Cells Cultured
Zdroj:	European Urology. 38:640-643
ISSN:	1421-993X 0302-2838
DOI:	10.1159/000020346
Popis:	To study the toxicity of latex urinary catheters on cultured human urothelial cells (HUC).We exposed monolayers of HUC (well characterized for their proliferation, qualitative evaluation and quantitative measurement of cytokeratins) to either pure or diluted liquid latex extracts, obtained under standard conditions or by direct contact with materials.The latex urinary catheter appears to be highly toxic since cell viability and metabolic activity were about 10% of those of negative controls for original extracts. Concerning direct contact, latex reduced cell viability, metabolic activity and cell proliferation of HUC on days 1, 3 and 8.The high toxicity of latex on HUC is confirmed for extracts and direct contact. Therefore, it should no longer be used for urinary catheters.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::946d579c3447d2dfc1fbcec7b05e1a46 https://doi.org/10.1159/000020346 Zobrazit plný text záznamu