Where all the Roads Meet? A Crossover Perspective on Host Factors Regulating SARS-CoV-2 infection

Autor: Sneh Lata, Ritu Mishra, Ravi P. Arya, Pooja Arora, Anismrita Lahon, Akhil C. Banerjea, Vikas Sood
Rok vydání: 2021
Předmět:
DDX
DEAD-box RNA helicase
CDG1C
congenital disorder of N-linked glycosylation type 1C
CDGS
carbohydrate-deficient glycoprotein syndrome
RSV
Respiratory Syncytial Virus
CSNK2B
casein kinase 2 subunit beta
Review Article
VPS
vacuolar protein sorting
SREBP3
sterol regulatory element binding protein 3
Structural Biology
PP2A
protein phosphatase 2A
Clustered Regularly Interspaced Short Palindromic Repeats
ALG
Alpha-1
3-glucosyltransferase
TMPRSS2
transmembrane protease serine 2
HDACS
histone deacetylases
TLR
toll-like receptors
DENV
Dengue Virus
C1QTNF7
C1q and tumor necrosis factor-related protein 7
CIRV
Carnation Italian ringspot virus
VACV
vaccinia virus
HIV-1
Human Immunodeficiency Virus 1
LRRN2
leucine-rich repeat neuronal protein 2
HPV
Human Papilloma Virus
IAV
Influenza A virus
SBV
Schmallenberg virus
CRISPR
HSV-1
Herpes Simplex Virus-1
SNPs
single nucleotide polymorphisms
Host factors
EBV
Epstein–Barr virus
TMV
Tobacco Mosaic Virus
BCOR
BCL6 interacting co-repressor
COVID-19
coronavirus disease 19
CTRP
C1q complement/TNF-related protein
Host-Derived Cellular Factors
Viral diseases
ACE2
angiotensin-converting enzyme 2
VSV
Vesicular Somatitis Virus
CHIKV
Chikungunya Virus
HCV
Hepatitis C virus
Humans
COG
conserved oligomeric Golgi
RRA
robust-rank aggregation
Molecular Biology
Pandemics
ComputingMethodologies_COMPUTERGRAPHICS
Host Microbial Interactions
SARS-CoV-2
ARPP-19
cyclic adenosine monophosphate-regulated phosphoprotein 19
COVID-19
LIMA-1
LIM domain and actin binding-1
GDI2
GDP dissociation inhibitor beta
TBSV
Tomato bushy stunt virus
EPLIN
epithelial protein lost in neoplasm
HCC
hepatocellular carcinoma
SLC35B2
solute carrier family 35 member B2
Zdroj: Journal of Molecular Biology
ISSN: 1089-8638
Popis: Graphical abstract
COVID-19 caused by SARS-CoV-2 is the latest pandemic which has thrown the world into an unprecedented social and economic uncertainties along with huge loss to humanity. Identification of the host factors regulating the replication of SARS-CoV-2 in human host may help in the development of novel anti-viral therapies to combat the viral infection and spread. Recently, some research groups used genome-wide CRISPR/Cas screening to identify the host factors critical for the SARS-CoV-2 replication and infection. A comparative analysis of these significant host factors (p
Databáze: OpenAIRE
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