Reactive oxygen species in reproduction: harmful, essential or both?
| Autor: | Rachida Cadi, Noureddine Louanjli, O Aniq Filali, H Debbarh, K Mounaji, Smahane Aboulmaouahib, M Jamil, M Zarqaoui, Brahim Saadani |
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| Rok vydání: | 2020 |
| Předmět: |
Reproductive Techniques
Assisted DNA damage Endometriosis Embryonic Development Biology medicine.disease_cause Embryo Culture Techniques 03 medical and health sciences 0302 clinical medicine medicine Animals Humans 030304 developmental biology Cryopreservation 0303 health sciences 030219 obstetrics & reproductive medicine Embryogenesis Embryo Cell Biology Blastula Oocyte Culture Media Cell biology Oxidative Stress medicine.anatomical_structure Second messenger system Oocytes Female Reactive Oxygen Species Embryo quality Oxidative stress Polycystic Ovary Syndrome Developmental Biology |
| Zdroj: | Zygote. 28:255-269 |
| ISSN: | 1469-8730 0967-1994 |
| DOI: | 10.1017/s0967199420000179 |
| Popis: | SummaryThe process of embryonic development is crucial and radically influences preimplantation embryo competence. It involves oocyte maturation, fertilization, cell division and blastulation and is characterized by different key phases that have major influences on embryo quality. Each stage of the process of preimplantation embryonic development is led by important signalling pathways that include very many regulatory molecules, such as primary and secondary messengers. Many studies, bothin vivoandin vitro, have shown the importance of the contribution of reactive oxygen species (ROS) as important second messengers in embryo development. ROS may originate from embryo metabolism and/or oocyte/embryo surroundings, and their effect on embryonic development is highly variable, depending on the needs of the embryo at each stage of development and on their environment (in vivoor underin vitroculture conditions). Other studies have also shown the deleterious effects of ROS in embryo development, when cellular tissue production overwhelms antioxidant production, leading to oxidative stress. This stress is known to be the cause of many cellular alterations, such as protein, lipid, and DNA damage. Considering that the same ROS level can have a deleterious effect on the fertilizing oocyte or embryo at certain stages, and a positive effect at another stage of the development process, further studies need to be carried out to determine the rate of ROS that benefits the embryo and from what rate it starts to be harmful, this measured at each key phase of embryonic development. |
| Databáze: | OpenAIRE |
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