Clinical comparison of two Mexican coccidioidins
| Autor: | Toriello Concepcion, Rafael Laniado-Laborín, Arturo Aroch-Calderón, Amelia Pérez-Mejía, María del Rocío González-Martínez, María Eugenia Manjarrez-Zavala, Ivan Sammir Aranda-Uribe, Alfonso Hernández-Navarez, Gabriel Palma, María Antonieta Flores-Sánchez, Bertha Muñoz-Hernández, Sandra Miranda-Mauricio, Laura Rosio Castañón-Olivares |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Antigens Fungal Adolescent Veterinary (miscellaneous) Applied Microbiology and Biotechnology Microbiology Serology Coccidioidin Young Adult Medical microbiology Antigen Medicine Humans Coccidioides Positive test Adverse effect Mexico Aged Skin Tests Aged 80 and over Coccidioidomycosis biology business.industry Middle Aged biology.organism_classification United States Immunology Female Cutoff point business Agronomy and Crop Science |
| Zdroj: | Mycopathologia. 169(6) |
| ISSN: | 1573-0832 |
| Popis: | Coccidioidin, an extract from the saprophytic mycelial form of Coccidioides spp., has been a very useful antigen preparation both for skin and serological tests for coccidioidomycosis. Unfortunately, coccidioidin is not currently available for skin testing in the United States. Coccidioidin has been produced commercially in Mexico by a vaccine and reagents laboratory of the Mexican Federal Government. It also has been produced at the Microbiology Laboratory of the Faculty of Medicine, Universidad Nacional Autónoma de México exclusively as an antigen for research projects. The objective of the study was to compare both coccidioidins in their reactivity and safety when applied in humans. One hundred and eighty-four volunteers were tested; median age was 33 (range 14-82). When the cutoff point is set in 5 mm, 88 subjects (47.8%) had a positive test for the commercial coccidioidin and 76 (41.3%; CI(95%) 0.50, 1.15; P = 0.20) were positive with the research antigen. Seventy-five subjects were positive for both antigens and 96 were negative for both. Fifty-nine subjects (31.3%) reported an adverse reaction after the application of the antigen; they were mostly very mild local reactions. Mexican research coccidioidin is a safe and reliable antigen that can be used for the detection of coccidioidomycosis infection in mammals. |
| Databáze: | OpenAIRE |
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