e23D: database and visualization of A-to-I RNA editing sites mapped to 3D protein structures
| Autor: | Ninette Amariglio, Ron Unger, G. Rechavi, Oz Solomon, Eran Eyal |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Statistics and Probability Protein Data Bank (RCSB PDB) Theoretical models Genomics Biology computer.software_genre Biochemistry 03 medical and health sciences Mice Protein structure Animals Humans Databases Protein Molecular Biology Database Proteins Computer Science Applications Visualization Protein Structure Tertiary Computational Mathematics 030104 developmental biology Computational Theory and Mathematics RNA editing ModBase Drosophila RNA Editing computer Software |
| Zdroj: | Bioinformatics (Oxford, England). 32(14) |
| ISSN: | 1367-4811 |
| Popis: | Summary: e23D, a database of A-to-I RNA editing sites from human, mouse and fly mapped to evolutionary related protein 3D structures, is presented. Genomic coordinates of A-to-I RNA editing sites are converted to protein coordinates and mapped onto 3D structures from PDB or theoretical models from ModBase. e23D allows visualization of the protein structure, modeling of recoding events and orientation of the editing with respect to nearby genomic functional sites from databases of disease causing mutations and genomic polymorphism. Availability and Implementation: http://www.sheba-cancer.org.il/e23D Contact: oz.solomon@live.biu.ac.il or Eran.Eyal@sheba.health.gov.il |
| Databáze: | OpenAIRE |
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