Rearrangement of the T-cell receptor alpha, beta and gamma chain genes in chronic lymphocytic leukemia
| Autor: | John P. Di Vincenzo, Agnes Szigeti, Daniel H. Ryan, Andras Perl, János Fehér, Péter Gergely, George N. Abraham |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Cancer Research
Chronic lymphocytic leukemia Alpha (ethology) Biology Immunoglobulin kappa-Chains medicine Humans Gene Rearrangement beta-Chain T-Cell Antigen Receptor Beta (finance) Aged Gene Rearrangement B-Lymphocytes Gene Rearrangement gamma-Chain T-Cell Antigen Receptor Immunoglobulin mu-Chains T-cell receptor T-Cell Receptor Alpha-Beta Hematology Gene rearrangement medicine.disease Leukemia Lymphocytic Chronic B-Cell Molecular biology Blotting Southern Oncology Peripheral blood lymphocyte biology.protein Female Antibody Gene Rearrangement alpha-Chain T-Cell Antigen Receptor |
| Zdroj: | Leukemia Research. 14:131-137 |
| ISSN: | 0145-2126 |
| DOI: | 10.1016/0145-2126(90)90041-7 |
| Popis: | Simultaneous expression of mature B-cell and T-cell markers and subsequent abrogation of expression of the T-cell surface markers by cytotoxic chemotherapy was reported earlier in a patient (TG) with chronic lymphocytic leukemia (CLL). In addition to rearrangements of the immunoglobulin (Ig) gene loci correlating with phenotypic data, the T-cell receptor (TCR) alpha, beta and gamma chain genes also displayed clonal rearrangements in peripheral blood lymphocyte DNA of TG. The present case shows that in CLL cells not only the expression of B-cell and T-cell specific differentiation antigens but also the rearrangement of Ig as well as TCR alpha, beta and gamma genes may occur simultaneously. |
| Databáze: | OpenAIRE |
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