Solanum nigrum Polyphenol Extracts Inhibit Hepatic Inflammation, Oxidative Stress, and Lipogenesis in High-Fat-Diet-Treated Mice

Autor: Dai-Jung Chung, Ja-Jen Chang, Hsing-Yu Jao, Bo-Han Wen, Yi-Ju Lee, Chau-Jong Wang
Rok vydání: 2017
Předmět:
Male
0301 basic medicine
medicine.medical_specialty
AMP-Activated Protein Kinases
Biology
Diet
High-Fat
medicine.disease_cause
Lipid peroxidation
Mice
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Insulin resistance
Non-alcoholic Fatty Liver Disease
Internal medicine
medicine
Animals
Humans
PPAR alpha
Solanum nigrum
Carnitine O-Palmitoyltransferase
Triglyceride
Plant Extracts
Cholesterol
Lipogenesis
Fatty liver
Polyphenols
General Chemistry
Lipid Metabolism
medicine.disease
Mice
Inbred C57BL
Oxidative Stress
Fatty acid synthase
030104 developmental biology
Endocrinology
Liver
chemistry
Biochemistry
030220 oncology & carcinogenesis
biology.protein
Acyl Coenzyme A
Sterol Regulatory Element Binding Protein 1
General Agricultural and Biological Sciences
Oxidative stress
Zdroj: Journal of Agricultural and Food Chemistry. 65:9255-9265
ISSN: 1520-5118
0021-8561
DOI: 10.1021/acs.jafc.7b03578
Popis: Patients with diabetes, obesity, and hyperlipidemia are all high-risk groups for fatty liver; however, the mechanism of fatty liver formation is not completely understood. Studies have indicated that abnormal fat metabolism, oxidative stress, and insulin resistance are positively correlated with peroxidation and abnormal cytokine production. Recent studies have revealed that Solanum nigrum extracts (SNE) possess anti-inflammatory, antioxidation, antihyperlipidemia, and liver protection abilities. Therefore, the present study investigated the in vivo and in vitro effects of an SNE on nonalcoholic fatty liver (NAFL)-induced hepatitis. In vivo data demonstrated that the SNE reduced blood triglyceride, sugar, and cholesterol levels, as well as fat accumulation, oxidative stress, and lipid peroxidation in high-fat-diet-treated mice. The results indicated that the SNE downregulated the expression of fatty acid synthase, 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), and sterol regulatory element-binding proteins (SREBPs) through the AMP-activated protein kinase (AMPK) pathway and upregulated the expression of carnitine palmitoyltransferase 1 (CPT1) and peroxisome proliferator-activated receptor alpha. Furthermore, we prepared a Solanum nigrum polyphenol extract (SNPE) from the SNE; the SNPE reduced hepatic lipid (oleic acid) accumulation. Therefore, SNE have the potential to alleviate NAFL-induced hepatitis, and polyphenolic compounds are the main components of SNE. Moreover, SNE can be used to develop health-food products for preventing NAFL disease.
Databáze: OpenAIRE
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