Serum interleukin-6 in schizophrenic patients
| Autor: | Masashi Nibuya, Shigenobu Kanba, Toshio Nakaki, Naoko Maruo, Futoshi Shintani, Gohei Yagi, N. Kinoshita, Eiji Suzuki |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male medicine.medical_specialty Psychosis Adolescent medicine.medical_treatment Enzyme-Linked Immunosorbent Assay General Biochemistry Genetics and Molecular Biology Autoimmune Diseases Immune system Internal medicine medicine Humans Distribution (pharmacology) General Pharmacology Toxicology and Pharmaceutics Child Interleukin 6 biology Interleukin-6 business.industry Significant difference High serum General Medicine Middle Aged medicine.disease Endocrinology Cytokine Schizophrenia Child Preschool biology.protein Female business |
| Zdroj: | Life Sciences. 49:661-664 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(91)90112-o |
| Popis: | We examined serum interleukin-6 (IL-6) in 90 schizophrenic patients in remission and 90 normal controls using enzyme-linked immuno-sorbent assay (ELISA). We found a significant difference in variation between the schizophrenic and the control groups (F = 10.9, P less than .002). The difference in distribution was also statistically significant by Kolmogorov-Smirnov (chi-square = 45.0, P less than .001). Eight patients had aberrantly high serum levels of interleukin-6. Since the higher levels of IL-6 are characteristically found in several autoimmune disorders, our finding suggests a link between schizophrenia and immune response, which could be either autoimmune or a process induced by reactivation of viruses. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|