Determination of Zinc, Copper, Manganese, and Iron in Blood from Patients with Light-Sensitive Skin Diseases
| Autor: | Irene Horkay, H. Altmann, J. Krajczár, D.K. Teherani |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
medicine.medical_specialty
DNA Repair DNA damage Iron chemistry.chemical_element Mineralogy Photodermatosis Dermatology Zinc Manganese Skin Diseases Porphyrias Internal medicine medicine Humans Photosensitivity Disorders Whole blood Chemistry DNA medicine.disease Copper Endocrinology Porphyria Nucleotide excision repair |
| Zdroj: | Dermatology. 169:66-69 |
| ISSN: | 1421-9832 1018-8665 |
| DOI: | 10.1159/000249570 |
| Popis: | It is known that some trace elements have an influence on the repair of UV light induced DNA damage. We have detected certain alterations in the excision repair of patients with photodermatoses. In these investigations of screening character the levels of zinc, copper, manganese, and iron were measured by means of atomic absorption spectrophotometry in the whole blood of 31 patients with polymorphic light eruption and 27 patients with cutaneous porphyrias. In active stage of polymorphic light eruption decreased zinc, copper, and iron concentrations and an increased manganese content were found. In remission only the zinc level was lower. In the active stage of cutaneous porphyrias a decreased zinc and iron content as well as an increased manganese level could be detected. A presumable connection between the findings and the rate of the excision repair is discussed. |
| Databáze: | OpenAIRE |
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