Rechallenge with mTOR Inhibitors in Metastatic Renal Cell Carcinoma Patients Who Progressed on Previous mTOR Inhibitor Therapy
Autor: | Jacques Medioni, Gero Kramer, Agnes Maj-Hes, Florian Scotté, Pierre Combe, Reza Elaidi, Stéphane Oudard, Yohan Gornadha, Manuela Schmidinger |
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Rok vydání: | 2013 |
Předmět: |
Male
Cancer Research Renal cell carcinoma Carcinoma medicine Humans Everolimus Receptor Carcinoma Renal Cell Protein Kinase Inhibitors PI3K/AKT/mTOR pathway Aged Retrospective Studies Sirolimus business.industry TOR Serine-Threonine Kinases Retrospective cohort study General Medicine Middle Aged medicine.disease Discovery and development of mTOR inhibitors Kidney Neoplasms Temsirolimus Receptors Vascular Endothelial Growth Factor Treatment Outcome Oncology Cancer research Female business medicine.drug |
Zdroj: | Oncology. 85:8-13 |
ISSN: | 1423-0232 0030-2414 |
Popis: | Objective: To determine if mammalian target of rapamycin (mTOR) inhibitor (everolimus or temsirolimus) rechallenge in the third- or fourth-line setting after sequential use of a vascular endothelial growth factor receptor (VEGF)-targeted agent and an mTOR inhibitor is a feasible and effective treatment strategy in patients with metastatic renal cell carcinoma (mRCC). Methods: Patients who received a VEGF-targeted agent, an mTOR inhibitor and rechallenge with a second mTOR inhibitor at 2 institutions (Hôpital Européen Georges-Pompidou and Vienna Medical School) between 30 March 2001 and 15 September 2011 were included. Analyses of radiographic images were performed according to the Response Evaluation Criteria in Solid Tumors, version 1.0, to determine the objective response rate and treatment duration (TD). Results: Twelve patients met the inclusion criteria. Following 1 or 2 VEGF receptor-tyrosine kinase inhibitors, 7 patients firstly received everolimus and 5 patients received temsirolimus. Irrespective of treatment sequence, 6 of 12 patients (50%) responded to everolimus and 4 of 12 patients (33%) responded to temsirolimus; 3 patients (25%) did not respond to either. Median TDs (95% confidence interval) for everolimus → temsirolimus and temsirolimus → everolimus sequences were 10.3 months (8.8-19.2 months) and 5.8 months (2.9-19.3 months), respectively. Conclusions: Despite the limited number of patients, this highlights the feasibility of utilizing mTOR rechallenge as an integral part of sequential treatment strategies in mRCC. |
Databáze: | OpenAIRE |
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