T- wave axis deviation is associated with biomarkers of low-grade inflammation
Autor: | Marialaura, Bonaccio, Augusto, Di Castelnuovo, Livia, Rago, Amalia, de Curtis, Deodato, Assanelli, Fabio, Badilini, Martino, Vaglio, Simona, Costanzo, Mariarosaria, Persichillo, Chiara, Cerletti, Maria Benedetta, Donati, Giovanni, de Gaetano, Licia, Iacoviello, Rosanna, Ramacciato |
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Rok vydání: | 2015 |
Předmět: |
Adult
Male medicine.medical_specialty Heart Ventricles Lymphocyte Inflammation Comorbidity Motor Activity 030204 cardiovascular system & hematology Granulocyte Membrane Potentials Cohort Studies Pathogenesis Electrocardiography 03 medical and health sciences 0302 clinical medicine Heart Conduction System Internal medicine Odds Ratio medicine Humans Platelet Obesity Aged Hypertriglyceridemia Metabolic Syndrome business.industry Smoking Hematology Middle Aged medicine.disease Blood Cell Count C-Reactive Protein Cross-Sectional Studies Endocrinology medicine.anatomical_structure Italy Hyperglycemia Hypertension Educational Status Left axis deviation Female Metabolic syndrome medicine.symptom business Body mass index Biomarkers 030215 immunology |
Zdroj: | Thrombosis and Haemostasis. 114:1199-1206 |
ISSN: | 2567-689X 0340-6245 |
Popis: | SummaryT-wave axis deviation (TDev) may help identifying subjects at risk for major cardiac events and mortality, but the pathogenesis of TDev is not well established; in particular, the possible association between TDev and inflammation is unexplored and unknown. We aimed at investigating the association between low-grade inflammation and TDev abnormalities by conducting a cross-sectional analysis on 17,507 subjects apparently free from coronary heart and haematological diseases enrolled in the MOLI-SANI study. TDev was measured from a standard 12-lead resting electrocardiogram. High sensitivity (Hs) C-reactive protein (CRP), leukocyte (WBC) and platelet counts, neutrophil or granulocyte to lymphocyte ratios were used as markers of inflammation. In multivariable model subjects reporting high CRP levels had higher odds of having borderline and abnormal TDev (OR=1.70; 95 %CI: 1.53–1.90 and OR=1.72; 95 %CI: 1.23–2.41, respectively); the association was still significant, although reduced, after controlling for body mass index (OR=1.17; 95 %CI: 1.05–1.32, for borderline and OR=1.46; 95 %CI: 1.03–2.08, for abnormal). Similarly, higher neutrophil or granulocyte to lymphocyte ratios were associated with increased odds of having abnormal TDev. Neither platelet nor leukocyte counts were associated with abnormal TDev. The relationship between CRP with TDev abnormalities was significantly stronger in men, in non- obese or normotensive individuals, and in those without metabolic syndrome. In conclusion, C-reactive protein and some cellular biomarkers of inflammation such as granulocyte or neutrophil to lymphocyte ratios were independently associated with abnormal TDev, especially in subjects at low CVD risk. These results suggest that a low-grade inflammation likely contributes to the pathogenesis of T- wave axis deviation. |
Databáze: | OpenAIRE |
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