Adaptive growth changes in the liver remnant are affected by the size of hepatectomy in rats

Autor:	S. Dutoit-Hamilton, F. Viborg Mortensen, K. Jarlhelt Andersen, A. Riegels Knudsen, J. Randell Nyengaard, M. Meier
Rok vydání:	2018
Předmět:	0301 basic medicine Male medicine.medical_specialty medicine.medical_treatment Pathology and Forensic Medicine Muscle hypertrophy Remnant liver 03 medical and health sciences hepatic surgery 0302 clinical medicine Internal medicine medicine Animals Hepatectomy Rats Wistar liver regeneration Molecular Biology Cell Proliferation Hyperplasia Hepatology business.industry Chemistry Cell growth hepatocyte hyperplasia Gastroenterology posthepatectomy liver failure Cell Biology Hypertrophy Organ Size Original Articles hepatocyte hypertrophy medicine.disease Liver regeneration Liver Regeneration 030104 developmental biology Endocrinology Point of delivery medicine.anatomical_structure Liver 030220 oncology & carcinogenesis Hepatocyte Hepatocytes business
Zdroj:	Meier, M, Andersen, K J, Knudsen, A R, Nyengaard, J R, Hamilton-Dutoit, S & Mortensen, F V 2018, ' Adaptive growth changes in the liver remnant are affected by the size of hepatectomy in rats ', International Journal of Experimental Pathology, vol. 99, no. 4, pp. 150-157 . https://doi.org/10.1111/iep.12282
ISSN:	1365-2613
DOI:	10.1111/iep.12282
Popis:	In this study we investigated the dynamics of hepatocyte hyperplasia and hypertrophy in rats subjected to increasing sizes of partial hepatectomy (PH). A total of 104 rats were randomized according to the size of PH. On postoperative days (PODs) 1, 3 and 5, blood was drawn and the remnant liver removed for stereological analysis. Liver parameters and regeneration rate were significantly affected by size of PH. On POD 1, hepatocyte volumes had increased significantly in all PH groups. On POD 3, all groups showed hepatocyte volumes approximating baseline. On POD 5, hepatocyte volumes were significantly lower in PH (90) than in baseline, sham and PH (30) rats. Increasing hepatocyte proliferation was not observed following PH (30). Following PH (70), cell proliferation was significantly elevated on PODs 1 and 3, and following PH (90) on PODs 3 and 5. In conclusion, general hypertrophy of hepatocytes after different size of PH was followed by hepatocyte proliferation only in the liver remnant of PH (70) and PH (90).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::946215b1dc2cc9409245ac6f10c077ea https://pubmed.ncbi.nlm.nih.gov/30198172 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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