Age-related changes in sex steroid levels influence bone mineral density in healthy Indian men
| Autor: | K. Venkat, MM Arora, Pmp Singh, M. I. Khatkhatay, Meena Desai |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
musculoskeletal diseases
Adult Male medicine.medical_specialty Aging Bone density Endocrinology Diabetes and Metabolism Osteoporosis Osteocalcin Collagen Type I Bone remodeling Young Adult Sex hormone-binding globulin Absorptiometry Photon N-terminal telopeptide Bone Density Internal medicine Sex Hormone-Binding Globulin medicine Humans Testosterone Gonadal Steroid Hormones Bone mineral biology Estradiol business.industry Middle Aged medicine.disease Endocrinology Sex steroid biology.protein business Peptides Biomarkers |
| Zdroj: | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 20(6) |
| ISSN: | 1433-2965 |
| Popis: | Age-related changes in sex steroid levels and its contribution to variations in rate of bone loss among men is unclear. Although, Bio-T and Bio-E2 levels declined with age and depicted an association with BMD in healthy Indian men, Bio-E2 was found to be an independent predictor of BMD. Ethnicity influences sex steroid levels, therefore, their role in pathogenesis of low bone mass needs to be established in various populations. We assessed the extent of changes in sex steroid levels with age and related these to bone mineral density (BMD) in healthy Indian men. Total testosterone (TT), estradiol (E2), sex hormone-binding globulin (SHBG), PTH, osteocalcin (OC), and c-terminal telopeptide (CTX) were measured in 330 men aged 20–55 years and correlated with BMD measured by DXA. Both Bio-T (1% per year) and Bio-E2 (0.8% per year) levels decreased significantly in ageing men, whereas TT (0.4% per year) and E2 (0.3% per year) levels decreased only marginally with age. In contrast, SHBG (1.4% per year) and PTH (1% per year) levels increased significantly with age. Serum TT (r = 0.19, p = 0.01) and Bio-T (r = 0.2, p = 0.01) levels were associated positively with BMD at spine, whereas E2 and Bio-E2 levels were associated with BMD at spine [E 2 (r = 0.31, p |
| Databáze: | OpenAIRE |
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