Serum Folate and Depressive Symptoms Among Japanese Men and Women: A Cross-Sectional and Prospective Study
| Autor: | Akiko Nanri, Norio Mishima, Tetsuya Mizoue, Masao Sato, Masanori Ohta, Hitomi Hayabuchi |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Cross-sectional study Folic Acid Serum folate Asian People Japan Surveys and Questionnaires Internal medicine Prevalence Humans Medicine Prospective Studies Prospective cohort study Psychiatry Biological Psychiatry Depressive symptoms Depression (differential diagnoses) Depression business.industry Odds ratio Middle Aged Health Surveys Confidence interval Psychiatry and Mental health Cross-Sectional Studies Health survey Female business |
| Zdroj: | Psychiatry Research. 200:349-353 |
| ISSN: | 0165-1781 |
| Popis: | Although several studies have reported an association between blood folate concentrations and depressive symptoms, few studies have prospectively examined the association. This study aimed to investigate the cross-sectional and prospective associations between serum folate concentrations and depressive symptoms among Japanese. We analysed data among 545 subjects who participated in a health survey at the time of periodic check-up in 2009 for a cross-sectional association and among 272 subjects without depressive symptoms at baseline (in 2006) who responded to both baseline (2006) and follow-up (2009) surveys for prospective association. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression (CES-D) scale. In a cross-sectional analysis, serum folate concentrations were significantly associated with a decreased prevalence of depressive symptoms (CES-D scale of ≥16). Moreover, serum folate concentrations at baseline were significantly inversely associated with depressive symptoms after 3 years; the multivariate-adjusted odds ratios (95% confidence intervals) of depressive symptoms for the lowest through highest tertile categories of serum folate concentrations were 1.00 (reference), 0.66 (0.29–1.52) and 0.40 (0.16–0.99) ( P for trend=0.047). Our findings suggest that a higher serum folate may be associated with decreased risk of depressive symptoms in Japanese. |
| Databáze: | OpenAIRE |
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