Reply to letter to the editor: hypoglycemia and treatment with opioids
| Autor: | Marion Sassier, Reynald Le Boisselier, Joachim Alexandre, Léa Hamel-Sénécal, Ghada Miremont-Salamé, Véronique Lelong-Boulouard, Xavier Humbert, Basile Chrétien, Jean-Luc Faillie, Sophie Fedrizzi, Charles Dolladille |
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| Přispěvatelé: | Département de Pharmacologie [CHU Caen], CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Université de Caen Normandie (UNICAEN), Normandie Université (NU), Université de Caen Normandie - UFR Santé (UNICAEN Santé), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU), Hôpital Côte de Nacre [CHU Caen], Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Pharmacoepidemiologie et évaluation de l'impact des produits de santé sur les populations, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Bordeaux Segalen - Bordeaux 2-Université de Rouen Normandie (UNIROUEN), CHU Bordeaux [Bordeaux], Mobilités : Attention, Orientation et Chronobiologie (COMETE), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Signalisation, électrophysiologie et imagerie des lésions d’ischémie-reperfusion myocardique (SEILIRM), Service de Médecine générale [CHU Caen], Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Université Bordeaux Segalen - Bordeaux 2-Université de Rouen Normandie (UNIROUEN), Salvy-Córdoba, Nathalie |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Letter to the editor [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology business.industry General Medicine Class effect 030204 cardiovascular system & hematology Hypoglycemia [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences medicine.disease 3. Good health [SDV.SP] Life Sciences [q-bio]/Pharmaceutical sciences 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis medicine Pharmacology (medical) MESH: Analgesics Opioid Intensive care medicine business [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Zdroj: | Expert Opinion on Drug Safety Expert Opinion on Drug Safety, Informa Healthcare, 2019, 18 (12), pp.1265-1266. ⟨10.1080/14740338.2019.1673364⟩ |
| ISSN: | 1474-0338 1744-764X |
| DOI: | 10.1080/14740338.2019.1673364⟩ |
| Popis: | International audience; We thank Brož et al. for their interest in our study aiming to determine if drug-induced hypoglycemia could be a class effect for opioids [1] and for their useful comments.The French PharmacoVigilance Database (FPVD) contains a narrative description of cases provided by the declarant, which we examined for this study. The description of the report’s narrative in pharmacovigilance study is a complement to disproportionality analysis that may identify potential mechanisms underlying the associations found between drugs and adverse drug reactions. We are glad that they shared our interest in finding such mechanisms to further investigate the link between hypoglycemia and opioids. As they accurately mentioned, 45 of the 93 tramadol-associated hypoglycemia cases included in our descriptive study in the FPVD were related to diabetic patients. Indeed, hypoglycemia in these patients could have been favored by the antihyperglycemic treatment they received. We agree with them that sleepiness, one of the common side effect of opioids, combined to the use of those antihyperglycemic treatments could have been one of the factors leading to the onset of hypoglycemia in those patients. However, not all the reports mentioned sleepiness and the prescription of opioids appeared to be the trigger factor causing the hypoglycemia even in diabetic patients, regardless of the underlying mechanism. |
| Databáze: | OpenAIRE |
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