Development of novel nanoparticle for bone cancer
| Autor: | Ralph Santos-Oliveira, Michelle Alvares Sarcinelli, de Carvalho Sm, Albernaz Mde S, Weissmüller G, Beatriz Ferreira de Carvalho Patricio |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Biodistribution Materials science Polymers Polyesters Biomedical Engineering Pharmaceutical Science Medicine (miscellaneous) Nanoparticle Bioengineering Bone Neoplasms Pharmacology Bone tissue Injections chemistry.chemical_compound Organophosphorus Compounds In vivo Prolonged release medicine Animals General Materials Science Tissue Distribution Lactic Acid Rats Wistar Radionuclide Imaging EDTMP Staining and Labeling Bone cancer Bone metastasis Technetium medicine.disease Surgery Rats medicine.anatomical_structure chemistry Polyvinyl Alcohol Nanoparticles |
| Zdroj: | Journal of biomedical nanotechnology. 10(7) |
| ISSN: | 1550-7033 |
| Popis: | Bone metastasis is responsible for up to 99% of bone tumors. As no cure has yet to be discovered, available treatments simply strive to improve quality of life. One of such treatments is the use of EDTMP (ethylenediamine-tetramethylenephosphonic acid) labeled with Samarium-153, which has been shown to improve survival in 70-80% of patients treated. A major disadvantage of this radiopharmaceutical is its superficial delivery, resulting in the need for multiple doses. The current work describes novel polymeric nanoparticles of EDTMP and evaluation of their biodistribution in vivo. Nanoparticles were prepared using a double emulsion-solvent evaporation method and characterized by AFM (atomic force microscopy). Nanoparticles (200-500 nm) were then labeled with Technetium-99m for biodistribution analysis in healthy Wistar rats. Polymeric nanoparticles of EDTMP were observed to accumulate at bone tissue for long periods of time (150 min), resulting in prolonged release of EDTMP at the target site. This finding suggests that this novel pharmaceutical formulation of EDTMP provides better targeted delivery than free EDTMP and may be a more optimal treatment for management of bone metastasis pain. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|