Investigation of AKI with Early Biomarkers after Cardiac Surgery
| Autor: | Tulin Aydogdu Titiz, Emel Gündüz, Ikbal Ozen Kucukcetin, Huseyin Mutlu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty RD1-811 Urology Hemodynamics 030204 cardiovascular system & hematology Kidney urologic and male genital diseases 03 medical and health sciences Postoperative Complications 0302 clinical medicine Lipocalin-2 Risk Factors Diseases of the circulatory (Cardiovascular) system Humans Medicine Cystatin C Cardiac Surgical Procedures Stage (cooking) Risk factor biology urogenital system business.industry Interleukin-18 Acute kidney injury General Medicine Acute Kidney Injury medicine.disease female genital diseases and pregnancy complications Cardiac surgery CST3 protein human RC666-701 biology.protein Female Original Article Surgery Intraoperative Period Cardiology and Cardiovascular Medicine business Biomarkers Kidney disease |
| Zdroj: | Brazilian Journal of Cardiovascular Surgery, Volume: 35, Issue: 5, Pages: 722-731, Published: 22 APR 2020 Brazilian Journal of Cardiovascular Surgery v.35 n.5 2020 Brazilian Journal of Cardiovascular Surgery Sociedade Brasileira de Cirurgia Cardiovascular (SBCCV) instacron:SBCCV Brazilian Journal of Cardiovascular Surgery, Vol 35, Iss 5, Pp 722-731 (2020) |
| ISSN: | 1678-9741 |
| DOI: | 10.21470/1678-9741-2019-0178 |
| Popis: | Objective: To provide a new interpretation of the effect of intraoperative hemodynamic data on postoperative acute kidney injury (AKI) development and to determine the accuracy of some biomarkers which are thought to be the early markers of renal injury. Methods: One hundred adult patients who were connected to the heart-lung pump during open-heart surgery were included in this study. Hemodynamic data, oxygen delivery, and transfusions were recorded intraoperatively, and the preoperative and 3. postoperative hour cystatin C, interleukin-18 (IL-18), and neutrophil gelatinase-associated lipocalin (NGAL) parameters were measured for early detection of kidney damage. In the analysis, 95% significance level was used to determine the difference. Results: According to the Kidney Disease Improving Global Outcomes criterion, AKI developed in 24 patients, 18 of whom were stage 1, two were stage 2, and four were stage 3. AKI (+) patients had more transfusions in the intraoperative period and AKI development was a risk factor for postoperative complications. NGAL and IL-18 levels were found to be approximately two-fold in the postoperative period in AKI (+) patients, whereas cystatin C was not sensitive in AKI detection. Conclusion: AKI development increases the risk of postoperative complications. NGAL and IL-18 were successful in detecting AKI in the early postoperative period. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|