Oleic acid inhibits cholesteryl esterase and cholesterol utilization for testosterone synthesis in mouse leydig cells
| Autor: | Jitka Hanzalova, A. Wayne Meikle, Darrell K. Murray, Jose C. Cardoso de Sousa |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Oleic Acids Biology Esterase Mice chemistry.chemical_compound Endocrinology Internal medicine medicine Animals Testosterone Leydig cell Cholesterol Reverse cholesterol transport Leydig Cells Luteinizing Hormone Sterol Esterase Oleic acid medicine.anatomical_structure chemistry lipids (amino acids peptides and proteins) Luteinizing hormone Oleic Acid Lipoprotein |
| Zdroj: | Metabolism. 45:293-299 |
| ISSN: | 0026-0495 |
| DOI: | 10.1016/s0026-0495(96)90281-4 |
| Popis: | We have observed that nonesterified fatty acids (NEFA) inhibit testosterone synthesis in response to luteinizing hormone (LH) in mouse Leydig cells, possibly by affecting cholesterol utilization or endogenous concentrations. We have now studied the influence of oleic acid (OA) on the cellular content of cholesterol, hydrolysis of cholesterol esters, and steroidogenesis in isolated mouse Leydig cells. OA (700 micromol/L added with fatty acid-free [FAF] albumin, 3 g/dL) significantly (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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