Molecular and Clinical Insights into the Role and Significance of Mutated DNA Repair Genes in Bladder Cancer
| Autor: | Philip Abbosh, Elizabeth R. Plimack |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
DNA repair DNA damage Urology medicine.medical_treatment cisplatin Review Biology DNA damage response DNA sequencing 03 medical and health sciences 0302 clinical medicine medicine DNA damage repair Gene Cisplatin chemoresponse Bladder cancer Immunotherapy upper tract urothelial carcinoma medicine.disease body regions 030104 developmental biology Oncology 030220 oncology & carcinogenesis Cancer research Advanced bladder cancer bladder cancer immunotherapy medicine.drug |
| Zdroj: | Bladder Cancer (Amsterdam, Netherlands) |
| ISSN: | 2352-3735 2352-3727 |
| DOI: | 10.3233/blc-170129 |
| Popis: | DNA damage response and repair genes (DDR genes) are commonly mutated in bladder cancer. The biological impact of these mutations is an area of intense basic, translational, and clinical interest. As next generation sequencing increases its foothold in the treatment of localized and advanced bladder cancer, the role of DDR genes will continue to evolve. We review the inventory and biology of DDR genes in bladder cancer and describe known and candidate roles for loss of DDR genes to engender therapeutic susceptibilities to various anti-cancer agents. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|