Sex differences in the association between visceral adipose tissue and atherosclerosis in type 2 diabetes patients with normal bodyweight: A study in a Chinese population

Autor: Kun Xu, Qidong Zheng, Jianlin Shao, Lin Yang, Yuancheng Dai, Jingyuan Zhang, Yao Liang, Wenhao Huang, Yajun Liu, Jian Cheng, Yuping Pan, Mengyao Yang, Lijiang Tang, Changqing Du
Rok vydání: 2022
Předmět:
Zdroj: Journal of Diabetes Investigation. 14:92-101
ISSN: 2040-1124
2040-1116
Popis: To investigate the impact of visceral adipose tissue (VAT) on atherosclerosis in type 2 diabetes patients with normal bodyweight (OB[-]) in the Chinese population, and to further assess the sex-age differences between them.A total of 8,839 type 2 diabetes patients from two of the National Metabolic Management Centers in China were included in this study. Participants were classified into four groups by visceral fat area (VFA; cmThe VA(+)OB(-) prevalence was 3.7% among these participants. Patients with VA(+)OB(-) had the highest baPWV value (P 0.001) and the highest proportion of the tertile 3 of baPWV (P 0.001) among four groups, and were significantly associated with baPWV (standardized β = 0.026, P = 0.008). VFA was significantly related to tertile 2 to tertile 3 of baPWV in (OB[-]) type 2 diabetes patients, when compared with tertile 1 of baPWV, respectively. In sex-age stratified analysis, the association of VFA and the tertiles of baPWV showed sex differences. For the 55 years age stratification analysis, there was no age difference in the relationship between VFA and baPWV in (OB[-]) patients.Increased VAT was an independent risk factor for atherosclerosis in female type 2 diabetes patients with normal weight.
Databáze: OpenAIRE
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