Alterations in pulmonary vascular function in rats exposed to intermittent hypoxia
| Autor: | Bronwyn J. Thomas, Janet C. Wanstall |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
Serotonin medicine.medical_specialty Vasodilator Agents Vasodilation In Vitro Techniques Pulmonary Artery Muscle Smooth Vascular Potassium Chloride Right ventricular hypertrophy medicine.artery Internal medicine medicine Animals Vasoconstrictor Agents Rats Wistar Hypoxia Pharmacology Aorta Lung Endothelin-1 business.industry Ionomycin Intermittent hypoxia Hypoxia (medical) medicine.disease Pulmonary hypertension Acetylcholine Rats Endocrinology medicine.anatomical_structure 15-Hydroxy-11 alpha 9 alpha-(epoxymethano)prosta-5 13-dienoic Acid Pulmonary artery Endothelium Vascular medicine.symptom business |
| Zdroj: | European Journal of Pharmacology. 477:153-161 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/j.ejphar.2003.08.015 |
| Popis: | Vasoactive agents were examined in arteries from control rats and rats exposed to intermittent hypoxia (10% oxygen; 8 h/day) for 3, 5 or 20 days. Hypoxic rats developed right ventricular hypertrophy after 5 days, but became pulmonary hypertensive (elevated right ventricular systolic pressure; RVSP) only after 20 days. In pulmonary arteries (main and intralobar), responses to acetylcholine and ionomycin (endothelium-dependent vasodilators) were reduced after 20 and 5 days of intermittent hypoxia, whereas contractions to 5-hydroxytryptamine (5-HT) were enhanced (potency increase >10-fold) after 20, 5 and 3 days. Contractions to endothelin-1 and a thromboxane-mimetic, but not Ca-2divided by, were also increased. No changes in vascular function occurred in aorta. Since changes in pulmonary vascular function preceded the increase in RVSP they do not result from, but may contribute to, the development of hypoxia-induced pulmonary hypertension. If similar changes occur in humans, they may be important in conditions characterised by intermittent, as opposed to continuous, hypoxia. (C) 2003 Elsevier B.V. All rights reserved. |
| Databáze: | OpenAIRE |
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