Construction of Indoline-Fused Tetrahydroisoquinolines through a Domino Coupling Reaction Catalyzed by CuCoFe Layered Double Hydroxide
Autor: | Xiaoting Tian, Wei-You Zhou, Shixin Sun, Qun Chen, Zhi-Hui Zhang, Mingyang He, Kong Zhenji, Zhenzhen Xia, Anwei Wang |
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Rok vydání: | 2021 |
Předmět: | |
Zdroj: | Organic Letters. 23:6321-6325 |
ISSN: | 1523-7052 1523-7060 |
Popis: | A convenient catalytic protocol for efficiently constructing indoline-fused tetrahydroisoquinolines based on CuCoFe layered double hydroxide (LDH) has been described. Preliminary mechanistic studies show that indoline-fused tetrahydroisoquinolines are produced via domino coupling/cyclization reactions between tetrahydroisoquinolines and active methylene compounds, including malononitrile, malonates, and analogues. CuCoFe-LDH can accelerate the Csp3-Csp3 and Csp3-Csp2 formation reactions in a single step. The research thus presents a unique opportunity to develop a synthetic methodology for N-containing polycyclic compounds. |
Databáze: | OpenAIRE |
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