Construction of Indoline-Fused Tetrahydroisoquinolines through a Domino Coupling Reaction Catalyzed by CuCoFe Layered Double Hydroxide

Autor:	Xiaoting Tian, Wei-You Zhou, Shixin Sun, Qun Chen, Zhi-Hui Zhang, Mingyang He, Kong Zhenji, Zhenzhen Xia, Anwei Wang
Rok vydání:	2021
Předmět:	Organic Chemistry Single step Biochemistry Combinatorial chemistry Domino Coupling reaction Catalysis chemistry.chemical_compound chemistry Indoline Hydroxide Physical and Theoretical Chemistry Methylene Malononitrile
Zdroj:	Organic Letters. 23:6321-6325
ISSN:	1523-7052 1523-7060
Popis:	A convenient catalytic protocol for efficiently constructing indoline-fused tetrahydroisoquinolines based on CuCoFe layered double hydroxide (LDH) has been described. Preliminary mechanistic studies show that indoline-fused tetrahydroisoquinolines are produced via domino coupling/cyclization reactions between tetrahydroisoquinolines and active methylene compounds, including malononitrile, malonates, and analogues. CuCoFe-LDH can accelerate the Csp3-Csp3 and Csp3-Csp2 formation reactions in a single step. The research thus presents a unique opportunity to develop a synthetic methodology for N-containing polycyclic compounds.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::944c6dab4f0881cf0cba46cb0fb766b7 https://doi.org/10.1021/acs.orglett.1c02059 Zobrazit plný text záznamu