Immunolocalization of two cytochrome P450 isozymes in rat nasal chemosensory tissue
| Autor: | Xinxin Ding, Ying Chen, Thomas V. Getchell, Marilyn L. Getchell |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Gene isoform
medicine.medical_specialty Vomeronasal organ Respiratory System Mucous membrane of nose Olfaction Biology Rats Sprague-Dawley Olfactory mucosa Cytochrome P-450 Enzyme System Olfactory Mucosa Internal medicine medicine Animals Nasal Septum Lamina propria Mucous Membrane General Neuroscience Mucus Cell biology Rats Isoenzymes Nasal Mucosa medicine.anatomical_structure Endocrinology Organ Specificity Transduction (physiology) |
| Zdroj: | Neuroreport. 3(9) |
| ISSN: | 0959-4965 |
| Popis: | The NMa and NMb isoforms of cytochrome P450 enzymes are expressed in three nasal chemosensory organs: the olfactory, septal and vomeronasal mucosae. The NMa isoform is widely distributed throughout the nasal mucosa whereas the NMb isoform is present primarily in the chemosensory mucosae. The localization of cytochromes P450 demonstrates that sustentacular cells in the olfactory and septal epithelia, the mucus of the vomeronasal organ and the acinar cells of glands in the lamina propria of all three chemosensory systems engage in xenobiotic metabolism and participate in odorant/pheromone clearance, a perireceptor process associated with chemosensory transduction. |
| Databáze: | OpenAIRE |
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