Ionophore-based optical nanosensors incorporating hydrophobic carbon dots and a pH-sensitive quencher dye for sodium detection
| Autor: | Kevin J. Cash, M. R. Behr, Anne A. Galyean |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Sodium
Inorganic chemistry Ionophore chemistry.chemical_element Biocompatible Materials 02 engineering and technology 010402 general chemistry 01 natural sciences Biochemistry Analytical Chemistry chemistry.chemical_compound Nanosensor pH indicator Quantum Dots Electrochemistry Nanotechnology Environmental Chemistry Spectroscopy Ionophores Chemistry Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology Photobleaching Carbon 0104 chemical sciences Quantum dot 0210 nano-technology Selectivity |
| Zdroj: | The Analyst. 143:458-465 |
| ISSN: | 1364-5528 0003-2654 |
| DOI: | 10.1039/c7an01382e |
| Popis: | Nanosensors present a biological monitoring method that is biocompatible, reversible, and nano-scale, and they offer many advantages over traditional organic indicators. Typical ionophore-based nanosensors incorporate nile-blue derivative pH indicators but suffer from photobleaching while quantum dot alternatives pose a potential toxicity risk. In order to address this challenge, sodium selective nanosensors containing carbon dots and a pH-sensitive quencher molecule were developed based on an ion-exchange theory and a decoupled recognition element from the pH indicator. Carbon dots were synthesized and integrated into nanosensors containing a pH-indicator, an analyte-binding ligand (ionophore), and a charge-balancing additive. These nanosensors are ion-selective against potassium (selectivity coefficient of 0.4) and lithium (selectivity coefficient of 0.9). Reversible nanosensor response to sodium is also demonstrated. The carbon dot nanosensors are resistant to changes in optical properties for at least 12 h and display stable selectivity to physiologically-relevant sodium (alpha = 0.5 of 200 mM NaCl) for a minimum of 6 days. |
| Databáze: | OpenAIRE |
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