New aromatic polyketides from the marine-derived fungus Pseudopithomyces maydicus PSU-AMF350 and their antimicrobial activity
| Autor: | Souwalak Phongpaichit, Baiq Nila Sari Ningsih, Jariya Sakayaroj, Vatcharin Rukachaisirikul, Sita Preedanon, Supansa Pansrinun |
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| Rok vydání: | 2021 |
| Předmět: |
biology
Hydroquinone 010405 organic chemistry Organic Chemistry Diphenyl ether Plant Science Fungus biology.organism_classification Antimicrobial 01 natural sciences Biochemistry 0104 chemical sciences Analytical Chemistry 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry Xanthone Organic chemistry |
| Zdroj: | Natural Product Research. 36:4982-4989 |
| ISSN: | 1478-6427 1478-6419 |
| DOI: | 10.1080/14786419.2021.1915309 |
| Popis: | Four new aromatic polyketides including two diphenyl ethers (pseudopithoethers A–B, 1-2), one benzofuranone (pseudopithonone, 3) and one xanthone (pseudopithoxanthone, 4), along with two known compounds (5-6) and one new naturally occurring hydroquinone (α,2,5-trihydroxyacetophenone, 7) were isolated from the marine-derived fungus Pseudopithomyces maydicus PSU-AMF350. Their structures were identified by analysis of spectroscopic data. All isolated compounds were tested for antimicrobial activity. Only compound 7 displayed antibacterial activity against methicillin-resistant Staphylococcus aureus with the MIC value of 128 µg/mL and against S. aureus, Acinetobacter baumannii NPRC005 and A. baumannii NPRC007 with the same MIC value of 200 µg/mL. |
| Databáze: | OpenAIRE |
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