Physical exercise down-regulated locomotor side effects induced by haloperidol treatment in Wistar rats
| Autor: | Mariana Fontoura Paim, Jocemar Ilha, Régis Gemerasca Mestriner, Patrícia Severo do Nascimento, Martina Blank, Léder Leal Xavier, Pedro Porto Alegre Baptista, Priscylla Nunes de Senna, Lisiani Saur, Matilde Achaval, Monica R. M. Vianna |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Lameness Animal medicine.medical_treatment Clinical Biochemistry Physical exercise Toxicology Biochemistry Behavioral Neuroscience Dopamine Physical Conditioning Animal medicine Haloperidol Animals Rats Wistar Saline Biological Psychiatry Pharmacology Dystonia Behavior Animal Parkinsonism medicine.disease Gait Rats Disease Models Animal Lameness Anesthesia Exploratory Behavior Dopamine Antagonists Psychology Locomotion medicine.drug |
| Zdroj: | Pharmacology Biochemistry and Behavior. 104:113-118 |
| ISSN: | 0091-3057 |
| DOI: | 10.1016/j.pbb.2012.12.020 |
| Popis: | Extra-pyramidal symptoms (EPS) such as akinesia, dystonia, gait alteration and tremors are observed when dopamine D2-receptors are blocked by pharmacological agents such as haloperidol. These alterations produce a Parkinson disease-like state (PLS). Physical exercise has been proven to improve gait and locomotor symptoms in Parkinson's disease; we sought to elucidate the effects of physical exercise on PLS induced by chronic administration of haloperidol in rats. We used 48 rats distributed into four groups: Control, Exercise, Haloperidol, and Hal+Exe. All the animals received a daily injection of saline or haloperidol for 30 days, and the exercise groups underwent a daily 30-minute exercise protocol for 20 days. The animals were subjected to the ink-paw test, bar test and open-field test throughout the training period. The haloperidol-induced akinesia increased throughout the days of injections, but exercise was shown to alleviate it. The assessment showed shortened stride length and increased stance width with the use of haloperidol, which were significantly alleviated by exercise. These results indicate that exercise could be an interesting approach towards reducing unwanted EPS caused by haloperidol. |
| Databáze: | OpenAIRE |
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