Osteopontin is associated with decreased apoptosis and αv integrin expression in lung adenocarcinoma
| Autor: | Ljiljana Bulat-Kardum, Nives Jonjić, Aldo Ivančić, Ksenija Lučin, Christophe Štemberger, Manuela Avirović, Koviljka Matušan-Ilijaš |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Lung Neoplasms Histology Cell Adenocarcinoma of Lung Apoptosis Adenocarcinoma Metastasis stomatognathic system medicine Humans Osteopontin Lung Aged Aged 80 and over biology Cell migration Cell Biology General Medicine Integrin alphaV Middle Aged medicine.disease medicine.anatomical_structure Tumor progression biology.protein Immunohistochemistry Female osteopontin αv integrin tissue array analysis immunohistochemistry aoptosis |
| Popis: | Osteopontin (OPN) is a glycoprotein involved in invasion, progression and metastasis of many carcinomas. It contains several functional domains including binding sites for αv integrins, cell surface molecules playing a major role in mediating cell migration and adhesion. The aim of the study was to evaluate the expression of osteopontin in human non-small cell lung cancer (NSCLC) and to determine its possible prognostic significance as well as relation to apoptosis and αv integrin expression. We analyzed 111 surgically resected NSCLC for immunohistochemical expression of OPN and αv integrin. OPN expression was compared to apoptotic rate and clinicopathological parameters such as tumor size, histological grade, lymph node status, pT, and TNM stage. Apoptotic rate was measured by TUNEL staining method. OPN expression in NSCLC was significantly higher in lung adenocarcinomas (AC) then in squamous cell carcinomas (p |
| Databáze: | OpenAIRE |
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