Platelet-Tumor Cell Hybrid Membrane-Camouflaged Nanoparticles for Enhancing Therapy Efficacy in Glioma
| Autor: | Wu, Lingling, Li, Qin, Deng, Junjie, Shen, Jinglan, Xu, Weide, Yang, Wei, Chen, Bingyu, Du, Yaoqiang, Zhang, Wei, Ge, Feihang, Lei, Siyun, Li, Kaiqiang, Wang, Zhen |
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| Rok vydání: | 2021 |
| Předmět: |
Drug Carriers
Cell Membrane Organic Chemistry targeted delivery Biophysics Pharmaceutical Science hybrid membrane Antineoplastic Agents Bioengineering Glioma General Medicine biomimetic anticancer Biomaterials Mice Drug Delivery Systems International Journal of Nanomedicine Cell Line Tumor Drug Discovery β-mangostin Animals Nanoparticles Original Research |
| Zdroj: | International Journal of Nanomedicine |
| ISSN: | 1178-2013 |
| DOI: | 10.2147/ijn.s333279 |
| Popis: | Purpose Cell membrane-camouflaged nanoparticles (NPs) are drawing increasing attention because their surfaces acquire some characteristics of the cell membranes, making them a unique class of biomimetic materials for diverse applications. Modification of cell membrane or combination of different types of membranes can enhance their functionality. Methods We prepared platelet and tumor cell membrane camouflaged β-mangostin-loaded NPs, which were synthesized with platelet–C6 hybrid biomimetic coating, poly(lactic-co-glycolic acid), and β-mangostin (β-PCNPs). Then, we evaluated their targeting ability and anticancer activity against glioma in vitro and in vivo. Results Biomimetic coating enhanced active drug targeting and immune escape properties of nanocarrier in C6 and THP-1 cells, respectively, which improved their cytotoxicity. β-PCNPs were characterized to study the inherent properties of both source cells. Compared with bare β-NPs, β-PCNPs exhibited high tumor-targeting capability and induced apoptosis of C6 cells in vitro. Similarly, intravenous administration of drug through β-PCNPs resulted in enhanced tumor-targeting and exhibited excellent rate of inhibition of glioma tumor growth in mice. Moreover, the blood circulation time of drug in mice in the β-PCNP group was markedly prolonged and these mice exhibited better outcome than those in the β-NP group. Conclusion These results provide a new strategy of utilizing PCNPs as carriers for drug delivery, which improves the targeting efficiency and therapeutic efficacy of chemotherapeutic agents for glioma therapy. Graphical Abstract |
| Databáze: | OpenAIRE |
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