A prospective study of tuberculosis and HIV disease progression
| Autor: | Sonal S. Munsiff, Peter L. Alpert, Marc N. Gourevitch, Chee-Jen Chang, Robert S. Klein |
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| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Tuberculosis Time Factors Opportunistic infection Immunology HIV Infections Biology Mycobacterium tuberculosis Acquired immunodeficiency syndrome (AIDS) Risk Factors Virology Internal medicine medicine Confidence Intervals Immunology and Allergy Humans Prospective Studies Prospective cohort study Survival rate Proportional Hazards Models AIDS-Related Opportunistic Infections Proportional hazards model Hazard ratio medicine.disease biology.organism_classification CD4 Lymphocyte Count Survival Rate Disease Progression Regression Analysis Female New York City |
| Zdroj: | Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association. 19(4) |
| ISSN: | 1077-9450 |
| Popis: | OBJECTIVE To determine whether active tuberculosis alters the rate of progression of HIV infection in dually infected patients. METHODS HIV-seropositive patients at two Bronx, New York hospitals with tuberculosis confirmed by culture from July 1992 to February 1995, who survived the initial hospitalization for tuberculosis, were matched on gender, age, CD4+ percentage, and calendar time with HIV-seropositive patients without tuberculosis participating in a study of the natural history of HIV infection. Patients received follow-up observation prospectively until May 23, 1995 to determine survival rates and development of AIDS-defining opportunistic infections (OIs). RESULTS 70 patients had tuberculosis; 120 did not. Mean CD4+ percentages were 12.4% and 12.5%, respectively. At study entry, 27% of those with tuberculosis had prior AIDS-defining OIs other than tuberculosis, compared with 10% of those without tuberculosis (p = .004). In multivariate survival analysis, controlling for CD4+ level, tuberculosis was not an independent predictor of increased other causes of AIDS-related mortality. However, in a logistic regression model, independent predictors of subsequent OIs included tuberculosis (hazard ratio, 4.1; 95% confidence intervals [CI], 1.9, 8.7), CD4+ count |
| Databáze: | OpenAIRE |
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