Population genetics of coagulation factor XIIIB in three ethnic groups of Singapore
| Autor: | John S. H. Tay, J.B. Basair, Nilmani Saha, P.S. Low |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
China Aging Physiology Epidemiology Immunoblotting Ethnic group India Population genetics Locus (genetics) Mongoloid Biology Coagulation factor XIIIb Gene Frequency Ethnicity Genetics Humans Allele Singapore Polymorphism Genetic Factor XIII Malaysia Public Health Environmental and Occupational Health Female Isoelectric Focusing Negroid Demography |
| Zdroj: | Annals of Human Biology. 19:277-283 |
| ISSN: | 1464-5033 0301-4460 |
| DOI: | 10.1080/03014469200002142 |
| Popis: | SummaryThe distribution of plasma coagulation factor XXIIB polymorphism was determined by PAG isoelectirc focusing and immunoblotting in a group of 670 subjects comprising 375 Chinese, 110 Malays and 185 Indians. The frequencies of FXIIIB*1, FXIIIB*2, and FXIIIB*3 were found to be 0·27, 0·03 and 0·70 in the Chinese; 0·33, 0·05 and 0·64 in the Malays and 0·58, 0·08 and 0·33 in the Indians. The phenotypic distribution of FXIIIB alleles was at Hardy-Weinberg equilibrium in all three populations. A two-dimensional principal-components analysis on the basis of three common alleles at the FXIIIB locus among 19 populations, so far studied, clearly differentiates the Negroid, Mongoloid and Caucasoid populations into three major groups with the exception of Amerindians (Minnesota) and US Blacks showing some Caucasoid influence. |
| Databáze: | OpenAIRE |
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