The Effect of Oral Leucine on Protein Metabolism in Adolescents with Type 1 Diabetes Mellitus
| Autor: | Margaret A. McNurlan, Jeremy Garlick, Thomas A. Wilson, Andrew H. Lane, Vardhini Desikan, Izolda Mileva |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Protein metabolism 030209 endocrinology & metabolism Protein degradation lcsh:Diseases of the endocrine glands. Clinical endocrinology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Diabetes mellitus medicine 030304 developmental biology chemistry.chemical_classification 0303 health sciences Type 1 diabetes lcsh:RC648-665 business.industry Insulin lcsh:RJ1-570 lcsh:Pediatrics medicine.disease Amino acid Endocrinology chemistry Basal (medicine) Leucine business Research Article |
| Zdroj: | International Journal of Pediatric Endocrinology International Journal of Pediatric Endocrinology, Vol 2010 (2010) |
| ISSN: | 1687-9856 1687-9848 |
| Popis: | Lack of insulin results in a catabolic state in subjects with insulin-dependent diabetes mellitus which is reversed by insulin treatment. Amino acid supply, especially branched chain amino acids such as leucine, enhances protein synthesis in both animal and human studies. This small study was undertaken to assess the acute effect of supplemental leucine on protein metabolism in adolescents with type 1 diabetes. L-[1-13C] Leucine was used to assess whole-body protein metabolism in six adolescent females (16–18 yrs) with type 1 diabetes during consumption of a basal diet (containing 58 μ moles leucine/kg/h) and the basal diet with supplemental leucine (232 μ moles leucine/kg/h). Net leucine balance was significantly higher with supplemental leucine ( μ moles leucine/kg body weight/hr) than with the basal diet ( , ) due to reduced protein degradation ( μ moles leucine/kg body weight/hr) compared to the basal diet ( , ). |
| Databáze: | OpenAIRE |
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