Regression of Experimental Human Leukemias and Solid Tumors Induced by Epstein-Barr Virus-Immortalized B Cells
| Autor: | Cecila Sgadari, Gregory H. Reaman, Annel L. Angiolillo, Giovanna Tosato, Nasreen M. Sheikh |
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| Rok vydání: | 1995 |
| Předmět: |
Acute promyelocytic leukemia
Herpesvirus 4 Human Cancer Research Transplantation Heterologous Athymic mouse Mice Nude medicine.disease_cause Mice hemic and lymphatic diseases Acute lymphocytic leukemia Neuroblastoma medicine Animals Humans B-Lymphocytes Mice Inbred BALB C Neovascularization Pathologic business.industry Wilms' tumor Neoplasms Experimental Hematology Cell Transformation Viral medicine.disease Burkitt Lymphoma Epstein–Barr virus Lymphoma Leukemia Oncology Immunology Cancer research business Neoplasm Transplantation |
| Zdroj: | Leukemia & Lymphoma. 19:267-276 |
| ISSN: | 1029-2403 1042-8194 |
| Popis: | We previously have reported on an experimental athymic mouse model in which regression of human Burkitt's lymphoma is induced by either coinjection with or intratumor inoculation of Epstein-Barr virus (EBV)-immortalized human B cells. In the current study, we were interested in determining whether the powerful antitumor effects of EBV-immortalized B cells could be effective against a variety of human tumors grown in athymic mice, including acute lymphocytic leukemia, malignant melanoma, acute promyelocytic leukemia, neuroblastoma, lung carcinoma, colon adenocarcinoma, Wilms tumor, Hodgkin's lymphoma, rhabdomyosarcoma and breast adenocarcinoma. We report here the results of experiments in nude mice that demonstrated the potent antitumor effect of EBV-immortalized B cells against human tumors derived from a variety of different tissues. |
| Databáze: | OpenAIRE |
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