Significant locus and metabolic genetic correlations revealed in genome-wide association study of anorexia nervosa
Autor: | Duncan, Laramie, Yilmaz, Zeynep, Gaspar, Helena, Walters, Raymond, Goldstein, Jackie, Anttila, Verneri, Bulik-Sullivan, Brendan, Ripke, Stephan, Thornton, Laura, Hinney, Anke, Daly, Mark, Sullivan, Patrick F., Zeggini, Eleftheria, Breen, Gerome, Bulik, Cynthia M., Gaspar, Héléna, Adan, Roger, Alfredsson, Lars, Ando, Tetsuya, Andreassen, Ole, Aschauer, Harald, Baker, Jessica, Barrett, Jeffrey, Bencko, Vladimir, Bergen, Andrew, Berrettini, Wade, Birgegård, Andreas, Boni, Claudette, Perica, Vesna Boraska, Brandt, Harry, Burghardt, Roland, Carlberg, Laura, Cassina, Matteo, Cesta, Carolyn, Cichon, Sven, Clementi, Maurizio, Cohen-Woods, Sarah, Coleman, Joni, Cone, Roger, Courtet, Philippe, Crawford, Steven, Crow, Scott, Crowley, Jim, Danner, Unna, Davis, Oliver, de Zwaan, Martina, Dedoussis, George, Degortes, Daniela, Desocio, Janiece, Danielle, Dick, Dikeos, Dimitris, Dina, Christian, Ding, Bo, Dmitrzak-Weglarz, Monika, Docampo, Elisa, Egberts, Karin, Ehrlich, Stefan, Escaramís, Geòrgia, Esko, Tõnu, Espeseth, Thomas, Estivill, Xavier, Favaro, Angela, Fernández-Aranda, Fernando, Fichter, Manfred, Finan, Chris, Fischer, Krista, Floyd, James, Föcker, Manuel, Foretova, Lenka, Forzan, Monica, Fox, Caroline, Franklin, Christopher, Gaborieau, Valerie, Gallinger, Steven, Gambaro, Giovanni, Giegling, Ina, Gonidakis, Fragiskos, Gorwood, Philip, Gratacos, Monica, Guillaume, Sébastien, Guo, Yiran, Hakonarson, Hakon, Halmi, Katherine, Harrison, Rebecca, Hatzikotoulas, Konstantinos, Hauser, Joanna, Hebebrand, Johannes, Helder, Sietske, Hendriks, Judith, Herms, Stefan, Herpertz-Dahlmann, Beate, Herzog, Wolfgang, Hilliard, Christopher, Huckins, Laura, Hudson, James, Huemer, Julia, Imgart, Hartmut, Inoko, Hidetoshi, Jall, Sigrid, Jamain, Stephane, Janout, Vladimir, Jiménez-Murcia, Susana, Johnson, Craig, Jordan, Jenny, Julià, Antonio, Juréus, Anders, Kalsi, Gursharan, Kaplan, Allan, Kaprio, Jaakko, Karhunen, Leila, Karwautz, Andreas, Kas, Martien, Kaye, Walter, Kennedy, Martin, Kennedy, James, Keski-Rahkonen, Anna, Kiezebrink, Kirsty, Kim, Youl-Ri, Klareskog, Lars, Klump, Kelly, Knudsen, Gun Peggy, Koeleman, Bobby, Koubek, Doris, La Via, Maria, Landén, Mikael, Le Hellard, Stephanie, Leboyer, Marion, Levitan, Robert, Dong, Li, Lichtenstein, Paul, Lilenfeld, Lisa, Lissowska, Jolanta, Lundervold, Astri, Magistretti, Pierre, Maj, Mario, Mannik, Katrin, Marsal, Sara, Kaminska, Debora, Martin, Nicholas, Mattingsdal, Morten, Mcdevitt, Sara, Mcguffin, Peter, Merl, Elisabeth, Metspalu, Andres, Meulenbelt, Ingrid, Micali, Nadia, Mitchell, James, Mitchell, Karen, Monteleone, Palmiero, Monteleone, Alessio Maria, Montgomery, Grant, Mortensen, Preben, Munn-Chernoff, Melissa, Müller, Timo, Nacmias, Benedetta, Navratilova, Marie, Nilsson, Ida, Norring, Claes, Ntalla, Ioanna, Ophoff, Roel, O’Toole, Julie, Palotie, Aarno, Pantel, Jacques, Papezova, Hana, Parker, Richard, Pinto, Dalila, Rabionet, Raquel, Raevuori, Anu, Rajewski, Andrzej, Ramoz, Nicolas, William Rayner, N., Reichborn-Kjennerud, Ted, Ricca, Valdo, Ripatti, Samuli, Ritschel, Franziska, Roberts, Marion, Rotondo, Alessandro, Rujescu, Dan, Rybakowski, Filip, Santonastaso, Paolo, Scherag, André, Scherer, Stephen, Schmidt, Ulrike, Schork, Nicholas, Schosser, Alexandra, Scott, Laura, Seitz, Jochen, Slachtova, Lenka, Sladek, Robert, Eline Slagboom, P., Slof-Op ’t Landt, Margarita, Slopien, Agnieszka, Smith, Tosha, Soranzo, Nicole, Sorbi, Sandro, Southam, Lorraine, Steen, Vidar, Strengman, Eric, Strober, Michael, Szatkiewicz, Jin, Szeszenia-Dabrowska, Neonila, Tachmazidou, Ioanna, Tenconi, Elena, Tortorella, Alfonso, Tozzi, Federica, Treasure, Janet, Tschöp, Matthias, Tsitsika, Artemis, Tziouvas, Konstantinos, van Elburg, Annemarie, van Furth, Eric, Wade, Tracey, Wagner, Gudrun, Walton, Esther, Watson, Hunna, Wichmann, H-Erich, Widen, Elisabeth, Woodside, Blake, Yanovski, Jack, Yao, Shuyang, Zerwas, Stephanie, Zipfel, Stephan |
---|---|
Přispěvatelé: | Duncan, Laramie, Yilmaz, Zeynep, Gaspar, Helena, Walters, Raymond, Goldstein, Jackie, Anttila, Verneri, Bulik-Sullivan, Brendan, Ripke, Stephan, Thornton, Laura, Hinney, Anke, Daly, Mark, Sullivan, Patrick F., Zeggini, Eleftheria, Breen, Gerome, Bulik, Cynthia M., Gaspar, Hã©lã©na, Adan, Roger, Alfredsson, Lar, Ando, Tetsuya, Andreassen, Ole, Aschauer, Harald, Baker, Jessica, Barrett, Jeffrey, Bencko, Vladimir, Bergen, Andrew, Berrettini, Wade, Birgegã¥rd, Andrea, Boni, Claudette, Perica, Vesna Boraska, Brandt, Harry, Burghardt, Roland, Carlberg, Laura, Cassina, Matteo, Cesta, Carolyn, Cichon, Sven, Clementi, Maurizio, Cohen-Woods, Sarah, Coleman, Joni, Cone, Roger, Courtet, Philippe, Crawford, Steven, Crow, Scott, Crowley, Jim, Danner, Unna, Davis, Oliver, de Zwaan, Martina, Dedoussis, George, Degortes, Daniela, Desocio, Janiece, Danielle, Dick, Dikeos, Dimitri, Dina, Christian, Ding, Bo, Dmitrzak-Weglarz, Monika, Docampo, Elisa, Egberts, Karin, Ehrlich, Stefan, Escaramãs, Geã²rgia, Esko, Tãµnu, Espeseth, Thoma, Estivill, Xavier, Favaro, Angela, Fernández-Aranda, Fernando, Fichter, Manfred, Finan, Chri, Fischer, Krista, Floyd, Jame, Fã¶cker, Manuel, Foretova, Lenka, Forzan, Monica, Fox, Caroline, Franklin, Christopher, Gaborieau, Valerie, Gallinger, Steven, Gambaro, Giovanni, Giegling, Ina, Gonidakis, Fragisko, Gorwood, Philip, Gratacos, Monica, Guillaume, Sã©bastien, Guo, Yiran, Hakonarson, Hakon, Halmi, Katherine, Harrison, Rebecca, Hatzikotoulas, Konstantino, Hauser, Joanna, Hebebrand, Johanne, Helder, Sietske, Hendriks, Judith, Herms, Stefan, Herpertz-Dahlmann, Beate, Herzog, Wolfgang, Hilliard, Christopher, Huckins, Laura, Hudson, Jame, Huemer, Julia, Imgart, Hartmut, Inoko, Hidetoshi, Jall, Sigrid, Jamain, Stephane, Janout, Vladimir, Jiménez-Murcia, Susana, Johnson, Craig, Jordan, Jenny, Juliã , Antonio, Jurã©us, Ander, Kalsi, Gursharan, Kaplan, Allan, Kaprio, Jaakko, Karhunen, Leila, Karwautz, Andrea, Kas, Martien, Kaye, Walter, Kennedy, Martin, Kennedy, Jame, Keski-Rahkonen, Anna, Kiezebrink, Kirsty, Kim, Youl-Ri, Klareskog, Lar, Klump, Kelly, Knudsen, Gun Peggy, Koeleman, Bobby, Koubek, Dori, La Via, Maria, Landã©n, Mikael, Le Hellard, Stephanie, Leboyer, Marion, Levitan, Robert, Li, Dong, Lichtenstein, Paul, Lilenfeld, Lisa, Lissowska, Jolanta, Lundervold, Astri, Magistretti, Pierre, Maj, Mario, Mannik, Katrin, Marsal, Sara, Kaminska, Debora, Martin, Nichola, Mattingsdal, Morten, Mcdevitt, Sara, Mcguffin, Peter, Merl, Elisabeth, Metspalu, Andre, Meulenbelt, Ingrid, Micali, Nadia, Mitchell, Jame, Mitchell, Karen, Monteleone, Palmiero, Monteleone, Alessio Maria, Montgomery, Grant, Mortensen, Preben, Munn-Chernoff, Melissa, Mã¼ller, Timo, Nacmias, Benedetta, Navratilova, Marie, Nilsson, Ida, Norring, Clae, Ntalla, Ioanna, Ophoff, Roel, Oâ toole, Julie, Palotie, Aarno, Pantel, Jacque, Papezova, Hana, Parker, Richard, Pinto, Dalila, Rabionet, Raquel, Raevuori, Anu, Rajewski, Andrzej, Ramoz, Nicola, William Rayner, N., Reichborn-Kjennerud, Ted, Ricca, Valdo, Ripatti, Samuli, Ritschel, Franziska, Roberts, Marion, Rotondo, Alessandro, Rujescu, Dan, Rybakowski, Filip, Santonastaso, Paolo, Scherag, Andrã©, Scherer, Stephen, Schmidt, Ulrike, Schork, Nichola, Schosser, Alexandra, Scott, Laura, Seitz, Jochen, Slachtova, Lenka, Sladek, Robert, Eline Slagboom, P., Slof-Op â t Landt, Margarita, Slopien, Agnieszka, Smith, Tosha, Soranzo, Nicole, Sorbi, Sandro, Southam, Lorraine, Steen, Vidar, Strengman, Eric, Strober, Michael, Szatkiewicz, Jin, Szeszenia-Dabrowska, Neonila, Tachmazidou, Ioanna, Tenconi, Elena, Tortorella, Alfonso, Tozzi, Federica, Treasure, Janet, Tschã¶p, Matthia, Tsitsika, Artemi, Tziouvas, Konstantino, van Elburg, Annemarie, van Furth, Eric, Wade, Tracey, Wagner, Gudrun, Walton, Esther, Watson, Hunna, Wichmann, H-Erich, Widen, Elisabeth, Woodside, Blake, Yanovski, Jack, Yao, Shuyang, Zerwas, Stephanie, Zipfel, Stephan, Universitat de Barcelona, Kas lab |
Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Linkage disequilibrium Anorexia Nervosa Eating Disorders Medizin Genome-wide association study Diabete Linkage Disequilibrium Diabetes GWAS Genetics Metabolism Case-Control Studies Genetic Predisposition to Disease Humans Phenotype Polymorphism Single Nucleotide Genome-Wide Association Study Psychiatry and Mental Health 0302 clinical medicine Anorexia Nervosa/genetics SCHIZOPHRENIA Gwas RISK Genetic Predisposition to Disease/genetics PSYCHIATRIC-DISORDERS Anorèxia nerviosa Eating Disorder Single Nucleotide Polymorphism Single Nucleotide/genetics Metabolisme Psychiatry and Mental health Psychology Case-Control Studie TRAITS Human Polymorphism Single-nucleotide polymorphism behavioral disciplines and activities Article Feeding and Eating Disorders 03 medical and health sciences Genetic mental disorders Journal Article Linkage Disequilibrium/genetics 1000 Genomes Project Bulimia Nervosa METAANALYSIS Genetic association EATING-DISORDERS Settore MED/13 - ENDOCRINOLOGIA Anorexia nervosa Heritability Minor allele frequency 030104 developmental biology UPDATE 030217 neurology & neurosurgery Imputation (genetics) Genètica Meta-Analysis |
Zdroj: | Duncan, L, Yilmaz, Z, Gaspar, H, Walters, R K, Goldstein, J, Anttila, V, Bulik-Sullivan, B K, Ripke, S, Thornton, L M, Hinney, A, Daly, M, Sullivan, P F, Zeggini, E, Breen, G, Bulik, C M, Eating Disorders Working Group of the Psychiatric Genomics Consortium & Mortensen, P B 2017, ' Significant Locus and Metabolic Genetic Correlations Revealed in Genome-Wide Association Study of Anorexia Nervosa ', American Journal of Psychiatry, vol. 174, no. 9, pp. 850-858 . https://doi.org/10.1176/appi.ajp.2017.16121402 Recercat. Dipósit de la Recerca de Catalunya instname American Journal of Psychiatry American Journal of Psychiatry, Vol. 174, No 9 (2017) pp. 850-858 Duncan, L, Yilmaz, Z, Gaspar, H, Walters, R, Goldstein, J, Anttila, V, Bulik-Sullivan, B, Ripke, S, Thornton, L, Hinney, A, Daly, M, Sullivan, P F, Zeggini, E, Breen, G, Bulik, C M, Duncan, L, Yilmaz, Z, Gaspar, H, Walters, R, Goldstein, J, Anttila, V, Bulik-Sullivan, B, Ripke, S, Adan, R, Alfredsson, L, Ando, T, Andreassen, O, Aschauer, H, Baker, J, Barrett, J, Bencko, V, Bergen, A, Berrettini, W, Birgegård, A, Boni, C, Perica, V B, Brandt, H, Burghardt, R, Carlberg, L, Cassina, M, Cesta, C, Cichon, S, Clementi, M, Cohen-Woods, S, Coleman, J, Cone, R, Courtet, P, Crawford, S, Crow, S, Crowley, J, Danner, U, Davis, O, de Zwaan, M, Dedoussis, G, Degortes, D, DeSocio, J, Danielle, D N, Dikeos, D, Dina, C, Ding, B, Dmitrzak-Weglarz, M, Docampo, E, Egberts, K, Ehrlich, S, Escaramís, G, Esko, T, Espeseth, T, Estivill, X, Favaro, A, Fernández-Aranda, F, Fichter, M, Finan, C, Fischer, K, Floyd, J, Föcker, M, Foretova, L, Forzan, M, Fox, C, Franklin, C, Gaborieau, V, Gallinger, S, Gambaro, G, Giegling, I, Gonidakis, F, Gorwood, P, Gratacos, M, Guillaume, S, Guo, Y, Hakonarson, H, Halmi, K, Harrison, R, Hatzikotoulas, K, Hauser, J, Hebebrand, J, Helder, S, Hendriks, J, Herms, S, Herpertz-Dahlmann, B, Herzog, W, Hilliard, C, Huckins, L, Hudson, J, Huemer, J, Imgart, H, Inoko, H, Jall, S, Jamain, S, Janout, V, Jiménez-Murcia, S, Johnson, C, Jordan, J, Julià, A, Juréus, A, Kalsi, G, Kaplan, A, Kaprio, J, Karhunen, L, Karwautz, A, Kas, M, Kaye, W, Kennedy, M, Kennedy, J, Keski-Rahkonen, A, Kiezebrink, K, Kim, Y R, Klareskog, L, Klump, K, Knudsen, G P, Koeleman, B, Koubek, D, La Via, M, Landén, M, Le Hellard, S, Leboyer, M, Levitan, R, Li, D, Lichtenstein, P, Lilenfeld, L, Lissowska, J, Lundervold, A, Magistretti, P, Maj, M, Mannik, K, Marsal, S, Kaminska, D, Martin, N, Mattingsdal, M, McDevitt, S, McGuffin, P, Merl, E, Metspalu, A, Meulenbelt, I, Micali, N, Mitchell, J, Mitchell, K, Monteleone, P, Monteleone, A M, Montgomery, G, Mortensen, P, Munn-Chernoff, M, Müller, T, Nacmias, B, Navratilova, M, Nilsson, I, Norring, C, Ntalla, I, Ophoff, R, O’Toole, J, Palotie, A, Pantel, J, Papezova, H, Parker, R, Pinto, D, Rabionet, R, Raevuori, A, Rajewski, A, Ramoz, N, William Rayner, N, Reichborn-Kjennerud, T, Ricca, V, Ripatti, S, Ritschel, F, Roberts, M, Rotondo, A, Rujescu, D, Rybakowski, F, Santonastaso, P, Scherag, A, Scherer, S, Schmidt, U, Schork, N, Schosser, A, Scott, L, Seitz, J, Slachtova, L, Sladek, R, Eline Slagboom, P, Slof-Op ’t Landt, M, Slopien, A, Smith, T, Soranzo, N, Sorbi, S, Southam, L, Steen, V, Strengman, E, Strober, M, Szatkiewicz, J, Szeszenia-Dabrowska, N, Tachmazidou, I, Tenconi, E, Tortorella, A, Tozzi, F, Treasure, J, Tschöp, M, Tsitsika, A, Tziouvas, K, van Elburg, A, van Furth, E, Wade, T, Wagner, G, Walton, E, Watson, H, Wichmann, H E, Widen, E, Woodside, B, Yanovski, J, Yao, S, Zerwas, S, Zipfel, S, Thornton, L, Hinney, A, Daly, M, Sullivan, P F, Zeggini, E, Breen, G & Bulik, C M 2017, ' Significant locus and metabolic genetic correlations revealed in genome-wide association study of anorexia nervosa ', American Journal of Psychiatry, vol. 174, no. 9, pp. 850-858 . https://doi.org/10.1176/appi.ajp.2017.16121402 American Journal of Psychiatry, 174(9), 850. American Psychiatric Association American Journal of Psychiatry, 174(9), 850-858. AMER PSYCHIATRIC PUBLISHING, INC Am. J. Psychiatry 174, 850-858 (2017) Dipòsit Digital de la UB Universidad de Barcelona |
ISSN: | 0002-953X |
Popis: | Objective: The authors conducted a genome-wide association study of anorexia nervosa and calculated genetic correlations with a series of psychiatric, educational, and metabolic phenotypes. Method: Following uniformquality control and imputation procedures using the 1000 Genomes Project (phase 3) in 12 case-control cohorts comprising 3, 495 anorexia nervosa cases and 10, 982 controls, the authors performed standard association analysis followed by a meta-analysis across cohorts. Linkage disequilibrium score regression was used to calculate genome-wide common variant heritability (single-nucleotide polymorphism [SNP]-based heritability [h2 SNP]), partitioned heritability, and genetic correlations (rg) between anorexia nervosa and 159 other phenotypes. Results: Results were obtained for 10, 641, 224 SNPs and insertion-deletion variants with minor allele frequencies.>1% and imputation quality scores >0.6. The h2 SNP of anorexia nervosa was 0.20 (SE=0.02), suggesting that a substantial fraction of the twin-based heritability arises from common genetic variation. The authors identified one genome-wide significant locus on chromosome 12 (rs4622308) in a region harboring a previously reported type 1 diabetes and autoimmune disorder locus. Significant positive genetic correlations were observed between anorexia nervosa and schizophrenia, neuroticism, educational attainment, and high-density lipoprotein cholesterol, and significant negative genetic correlations were observed between anorexia nervosa and body mass index, insulin, glucose, and lipid phenotypes. Conclusions: Anorexia nervosa is a complex heritable phenotype for which this study has uncovered the first genomewide significant locus. Anorexia nervosa also has large and significant genetic correlations with both psychiatric phenotypes and metabolic traits. The study results encourage a reconceptualization of this frequently lethal disorder as one with both psychiatric and metabolic etiology. |
Databáze: | OpenAIRE |
Externí odkaz: |