Significant locus and metabolic genetic correlations revealed in genome-wide association study of anorexia nervosa

Autor: Duncan, Laramie, Yilmaz, Zeynep, Gaspar, Helena, Walters, Raymond, Goldstein, Jackie, Anttila, Verneri, Bulik-Sullivan, Brendan, Ripke, Stephan, Thornton, Laura, Hinney, Anke, Daly, Mark, Sullivan, Patrick F., Zeggini, Eleftheria, Breen, Gerome, Bulik, Cynthia M., Gaspar, Héléna, Adan, Roger, Alfredsson, Lars, Ando, Tetsuya, Andreassen, Ole, Aschauer, Harald, Baker, Jessica, Barrett, Jeffrey, Bencko, Vladimir, Bergen, Andrew, Berrettini, Wade, Birgegård, Andreas, Boni, Claudette, Perica, Vesna Boraska, Brandt, Harry, Burghardt, Roland, Carlberg, Laura, Cassina, Matteo, Cesta, Carolyn, Cichon, Sven, Clementi, Maurizio, Cohen-Woods, Sarah, Coleman, Joni, Cone, Roger, Courtet, Philippe, Crawford, Steven, Crow, Scott, Crowley, Jim, Danner, Unna, Davis, Oliver, de Zwaan, Martina, Dedoussis, George, Degortes, Daniela, Desocio, Janiece, Danielle, Dick, Dikeos, Dimitris, Dina, Christian, Ding, Bo, Dmitrzak-Weglarz, Monika, Docampo, Elisa, Egberts, Karin, Ehrlich, Stefan, Escaramís, Geòrgia, Esko, Tõnu, Espeseth, Thomas, Estivill, Xavier, Favaro, Angela, Fernández-Aranda, Fernando, Fichter, Manfred, Finan, Chris, Fischer, Krista, Floyd, James, Föcker, Manuel, Foretova, Lenka, Forzan, Monica, Fox, Caroline, Franklin, Christopher, Gaborieau, Valerie, Gallinger, Steven, Gambaro, Giovanni, Giegling, Ina, Gonidakis, Fragiskos, Gorwood, Philip, Gratacos, Monica, Guillaume, Sébastien, Guo, Yiran, Hakonarson, Hakon, Halmi, Katherine, Harrison, Rebecca, Hatzikotoulas, Konstantinos, Hauser, Joanna, Hebebrand, Johannes, Helder, Sietske, Hendriks, Judith, Herms, Stefan, Herpertz-Dahlmann, Beate, Herzog, Wolfgang, Hilliard, Christopher, Huckins, Laura, Hudson, James, Huemer, Julia, Imgart, Hartmut, Inoko, Hidetoshi, Jall, Sigrid, Jamain, Stephane, Janout, Vladimir, Jiménez-Murcia, Susana, Johnson, Craig, Jordan, Jenny, Julià, Antonio, Juréus, Anders, Kalsi, Gursharan, Kaplan, Allan, Kaprio, Jaakko, Karhunen, Leila, Karwautz, Andreas, Kas, Martien, Kaye, Walter, Kennedy, Martin, Kennedy, James, Keski-Rahkonen, Anna, Kiezebrink, Kirsty, Kim, Youl-Ri, Klareskog, Lars, Klump, Kelly, Knudsen, Gun Peggy, Koeleman, Bobby, Koubek, Doris, La Via, Maria, Landén, Mikael, Le Hellard, Stephanie, Leboyer, Marion, Levitan, Robert, Dong, Li, Lichtenstein, Paul, Lilenfeld, Lisa, Lissowska, Jolanta, Lundervold, Astri, Magistretti, Pierre, Maj, Mario, Mannik, Katrin, Marsal, Sara, Kaminska, Debora, Martin, Nicholas, Mattingsdal, Morten, Mcdevitt, Sara, Mcguffin, Peter, Merl, Elisabeth, Metspalu, Andres, Meulenbelt, Ingrid, Micali, Nadia, Mitchell, James, Mitchell, Karen, Monteleone, Palmiero, Monteleone, Alessio Maria, Montgomery, Grant, Mortensen, Preben, Munn-Chernoff, Melissa, Müller, Timo, Nacmias, Benedetta, Navratilova, Marie, Nilsson, Ida, Norring, Claes, Ntalla, Ioanna, Ophoff, Roel, O’Toole, Julie, Palotie, Aarno, Pantel, Jacques, Papezova, Hana, Parker, Richard, Pinto, Dalila, Rabionet, Raquel, Raevuori, Anu, Rajewski, Andrzej, Ramoz, Nicolas, William Rayner, N., Reichborn-Kjennerud, Ted, Ricca, Valdo, Ripatti, Samuli, Ritschel, Franziska, Roberts, Marion, Rotondo, Alessandro, Rujescu, Dan, Rybakowski, Filip, Santonastaso, Paolo, Scherag, André, Scherer, Stephen, Schmidt, Ulrike, Schork, Nicholas, Schosser, Alexandra, Scott, Laura, Seitz, Jochen, Slachtova, Lenka, Sladek, Robert, Eline Slagboom, P., Slof-Op ’t Landt, Margarita, Slopien, Agnieszka, Smith, Tosha, Soranzo, Nicole, Sorbi, Sandro, Southam, Lorraine, Steen, Vidar, Strengman, Eric, Strober, Michael, Szatkiewicz, Jin, Szeszenia-Dabrowska, Neonila, Tachmazidou, Ioanna, Tenconi, Elena, Tortorella, Alfonso, Tozzi, Federica, Treasure, Janet, Tschöp, Matthias, Tsitsika, Artemis, Tziouvas, Konstantinos, van Elburg, Annemarie, van Furth, Eric, Wade, Tracey, Wagner, Gudrun, Walton, Esther, Watson, Hunna, Wichmann, H-Erich, Widen, Elisabeth, Woodside, Blake, Yanovski, Jack, Yao, Shuyang, Zerwas, Stephanie, Zipfel, Stephan
Přispěvatelé: Duncan, Laramie, Yilmaz, Zeynep, Gaspar, Helena, Walters, Raymond, Goldstein, Jackie, Anttila, Verneri, Bulik-Sullivan, Brendan, Ripke, Stephan, Thornton, Laura, Hinney, Anke, Daly, Mark, Sullivan, Patrick F., Zeggini, Eleftheria, Breen, Gerome, Bulik, Cynthia M., Gaspar, Hã©lã©na, Adan, Roger, Alfredsson, Lar, Ando, Tetsuya, Andreassen, Ole, Aschauer, Harald, Baker, Jessica, Barrett, Jeffrey, Bencko, Vladimir, Bergen, Andrew, Berrettini, Wade, Birgegã¥rd, Andrea, Boni, Claudette, Perica, Vesna Boraska, Brandt, Harry, Burghardt, Roland, Carlberg, Laura, Cassina, Matteo, Cesta, Carolyn, Cichon, Sven, Clementi, Maurizio, Cohen-Woods, Sarah, Coleman, Joni, Cone, Roger, Courtet, Philippe, Crawford, Steven, Crow, Scott, Crowley, Jim, Danner, Unna, Davis, Oliver, de Zwaan, Martina, Dedoussis, George, Degortes, Daniela, Desocio, Janiece, Danielle, Dick, Dikeos, Dimitri, Dina, Christian, Ding, Bo, Dmitrzak-Weglarz, Monika, Docampo, Elisa, Egberts, Karin, Ehrlich, Stefan, Escaramã­s, Geã²rgia, Esko, Tãµnu, Espeseth, Thoma, Estivill, Xavier, Favaro, Angela, Fernández-Aranda, Fernando, Fichter, Manfred, Finan, Chri, Fischer, Krista, Floyd, Jame, Fã¶cker, Manuel, Foretova, Lenka, Forzan, Monica, Fox, Caroline, Franklin, Christopher, Gaborieau, Valerie, Gallinger, Steven, Gambaro, Giovanni, Giegling, Ina, Gonidakis, Fragisko, Gorwood, Philip, Gratacos, Monica, Guillaume, Sã©bastien, Guo, Yiran, Hakonarson, Hakon, Halmi, Katherine, Harrison, Rebecca, Hatzikotoulas, Konstantino, Hauser, Joanna, Hebebrand, Johanne, Helder, Sietske, Hendriks, Judith, Herms, Stefan, Herpertz-Dahlmann, Beate, Herzog, Wolfgang, Hilliard, Christopher, Huckins, Laura, Hudson, Jame, Huemer, Julia, Imgart, Hartmut, Inoko, Hidetoshi, Jall, Sigrid, Jamain, Stephane, Janout, Vladimir, Jiménez-Murcia, Susana, Johnson, Craig, Jordan, Jenny, Juliã , Antonio, Jurã©us, Ander, Kalsi, Gursharan, Kaplan, Allan, Kaprio, Jaakko, Karhunen, Leila, Karwautz, Andrea, Kas, Martien, Kaye, Walter, Kennedy, Martin, Kennedy, Jame, Keski-Rahkonen, Anna, Kiezebrink, Kirsty, Kim, Youl-Ri, Klareskog, Lar, Klump, Kelly, Knudsen, Gun Peggy, Koeleman, Bobby, Koubek, Dori, La Via, Maria, Landã©n, Mikael, Le Hellard, Stephanie, Leboyer, Marion, Levitan, Robert, Li, Dong, Lichtenstein, Paul, Lilenfeld, Lisa, Lissowska, Jolanta, Lundervold, Astri, Magistretti, Pierre, Maj, Mario, Mannik, Katrin, Marsal, Sara, Kaminska, Debora, Martin, Nichola, Mattingsdal, Morten, Mcdevitt, Sara, Mcguffin, Peter, Merl, Elisabeth, Metspalu, Andre, Meulenbelt, Ingrid, Micali, Nadia, Mitchell, Jame, Mitchell, Karen, Monteleone, Palmiero, Monteleone, Alessio Maria, Montgomery, Grant, Mortensen, Preben, Munn-Chernoff, Melissa, Mã¼ller, Timo, Nacmias, Benedetta, Navratilova, Marie, Nilsson, Ida, Norring, Clae, Ntalla, Ioanna, Ophoff, Roel, Oâ toole, Julie, Palotie, Aarno, Pantel, Jacque, Papezova, Hana, Parker, Richard, Pinto, Dalila, Rabionet, Raquel, Raevuori, Anu, Rajewski, Andrzej, Ramoz, Nicola, William Rayner, N., Reichborn-Kjennerud, Ted, Ricca, Valdo, Ripatti, Samuli, Ritschel, Franziska, Roberts, Marion, Rotondo, Alessandro, Rujescu, Dan, Rybakowski, Filip, Santonastaso, Paolo, Scherag, Andrã©, Scherer, Stephen, Schmidt, Ulrike, Schork, Nichola, Schosser, Alexandra, Scott, Laura, Seitz, Jochen, Slachtova, Lenka, Sladek, Robert, Eline Slagboom, P., Slof-Op â t Landt, Margarita, Slopien, Agnieszka, Smith, Tosha, Soranzo, Nicole, Sorbi, Sandro, Southam, Lorraine, Steen, Vidar, Strengman, Eric, Strober, Michael, Szatkiewicz, Jin, Szeszenia-Dabrowska, Neonila, Tachmazidou, Ioanna, Tenconi, Elena, Tortorella, Alfonso, Tozzi, Federica, Treasure, Janet, Tschã¶p, Matthia, Tsitsika, Artemi, Tziouvas, Konstantino, van Elburg, Annemarie, van Furth, Eric, Wade, Tracey, Wagner, Gudrun, Walton, Esther, Watson, Hunna, Wichmann, H-Erich, Widen, Elisabeth, Woodside, Blake, Yanovski, Jack, Yao, Shuyang, Zerwas, Stephanie, Zipfel, Stephan, Universitat de Barcelona, Kas lab
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Linkage disequilibrium
Anorexia Nervosa
Eating Disorders
Medizin
Genome-wide association study
Diabete
Linkage Disequilibrium
Diabetes
GWAS
Genetics
Metabolism
Case-Control Studies
Genetic Predisposition to Disease
Humans
Phenotype
Polymorphism
Single Nucleotide
Genome-Wide Association Study
Psychiatry and Mental Health
0302 clinical medicine
Anorexia Nervosa/genetics
SCHIZOPHRENIA
Gwas
RISK
Genetic Predisposition to Disease/genetics
PSYCHIATRIC-DISORDERS
Anorèxia nerviosa
Eating Disorder
Single Nucleotide
Polymorphism
Single Nucleotide/genetics
Metabolisme
Psychiatry and Mental health
Psychology
Case-Control Studie
TRAITS
Human
Polymorphism
Single-nucleotide polymorphism
behavioral disciplines and activities
Article
Feeding and Eating Disorders
03 medical and health sciences
Genetic
mental disorders
Journal Article
Linkage Disequilibrium/genetics
1000 Genomes Project
Bulimia Nervosa
METAANALYSIS
Genetic association
EATING-DISORDERS
Settore MED/13 - ENDOCRINOLOGIA
Anorexia nervosa
Heritability
Minor allele frequency
030104 developmental biology
UPDATE
030217 neurology & neurosurgery
Imputation (genetics)
Genètica
Meta-Analysis
Zdroj: Duncan, L, Yilmaz, Z, Gaspar, H, Walters, R K, Goldstein, J, Anttila, V, Bulik-Sullivan, B K, Ripke, S, Thornton, L M, Hinney, A, Daly, M, Sullivan, P F, Zeggini, E, Breen, G, Bulik, C M, Eating Disorders Working Group of the Psychiatric Genomics Consortium & Mortensen, P B 2017, ' Significant Locus and Metabolic Genetic Correlations Revealed in Genome-Wide Association Study of Anorexia Nervosa ', American Journal of Psychiatry, vol. 174, no. 9, pp. 850-858 . https://doi.org/10.1176/appi.ajp.2017.16121402
Recercat. Dipósit de la Recerca de Catalunya
instname
American Journal of Psychiatry
American Journal of Psychiatry, Vol. 174, No 9 (2017) pp. 850-858
Duncan, L, Yilmaz, Z, Gaspar, H, Walters, R, Goldstein, J, Anttila, V, Bulik-Sullivan, B, Ripke, S, Thornton, L, Hinney, A, Daly, M, Sullivan, P F, Zeggini, E, Breen, G, Bulik, C M, Duncan, L, Yilmaz, Z, Gaspar, H, Walters, R, Goldstein, J, Anttila, V, Bulik-Sullivan, B, Ripke, S, Adan, R, Alfredsson, L, Ando, T, Andreassen, O, Aschauer, H, Baker, J, Barrett, J, Bencko, V, Bergen, A, Berrettini, W, Birgegård, A, Boni, C, Perica, V B, Brandt, H, Burghardt, R, Carlberg, L, Cassina, M, Cesta, C, Cichon, S, Clementi, M, Cohen-Woods, S, Coleman, J, Cone, R, Courtet, P, Crawford, S, Crow, S, Crowley, J, Danner, U, Davis, O, de Zwaan, M, Dedoussis, G, Degortes, D, DeSocio, J, Danielle, D N, Dikeos, D, Dina, C, Ding, B, Dmitrzak-Weglarz, M, Docampo, E, Egberts, K, Ehrlich, S, Escaramís, G, Esko, T, Espeseth, T, Estivill, X, Favaro, A, Fernández-Aranda, F, Fichter, M, Finan, C, Fischer, K, Floyd, J, Föcker, M, Foretova, L, Forzan, M, Fox, C, Franklin, C, Gaborieau, V, Gallinger, S, Gambaro, G, Giegling, I, Gonidakis, F, Gorwood, P, Gratacos, M, Guillaume, S, Guo, Y, Hakonarson, H, Halmi, K, Harrison, R, Hatzikotoulas, K, Hauser, J, Hebebrand, J, Helder, S, Hendriks, J, Herms, S, Herpertz-Dahlmann, B, Herzog, W, Hilliard, C, Huckins, L, Hudson, J, Huemer, J, Imgart, H, Inoko, H, Jall, S, Jamain, S, Janout, V, Jiménez-Murcia, S, Johnson, C, Jordan, J, Julià, A, Juréus, A, Kalsi, G, Kaplan, A, Kaprio, J, Karhunen, L, Karwautz, A, Kas, M, Kaye, W, Kennedy, M, Kennedy, J, Keski-Rahkonen, A, Kiezebrink, K, Kim, Y R, Klareskog, L, Klump, K, Knudsen, G P, Koeleman, B, Koubek, D, La Via, M, Landén, M, Le Hellard, S, Leboyer, M, Levitan, R, Li, D, Lichtenstein, P, Lilenfeld, L, Lissowska, J, Lundervold, A, Magistretti, P, Maj, M, Mannik, K, Marsal, S, Kaminska, D, Martin, N, Mattingsdal, M, McDevitt, S, McGuffin, P, Merl, E, Metspalu, A, Meulenbelt, I, Micali, N, Mitchell, J, Mitchell, K, Monteleone, P, Monteleone, A M, Montgomery, G, Mortensen, P, Munn-Chernoff, M, Müller, T, Nacmias, B, Navratilova, M, Nilsson, I, Norring, C, Ntalla, I, Ophoff, R, O’Toole, J, Palotie, A, Pantel, J, Papezova, H, Parker, R, Pinto, D, Rabionet, R, Raevuori, A, Rajewski, A, Ramoz, N, William Rayner, N, Reichborn-Kjennerud, T, Ricca, V, Ripatti, S, Ritschel, F, Roberts, M, Rotondo, A, Rujescu, D, Rybakowski, F, Santonastaso, P, Scherag, A, Scherer, S, Schmidt, U, Schork, N, Schosser, A, Scott, L, Seitz, J, Slachtova, L, Sladek, R, Eline Slagboom, P, Slof-Op ’t Landt, M, Slopien, A, Smith, T, Soranzo, N, Sorbi, S, Southam, L, Steen, V, Strengman, E, Strober, M, Szatkiewicz, J, Szeszenia-Dabrowska, N, Tachmazidou, I, Tenconi, E, Tortorella, A, Tozzi, F, Treasure, J, Tschöp, M, Tsitsika, A, Tziouvas, K, van Elburg, A, van Furth, E, Wade, T, Wagner, G, Walton, E, Watson, H, Wichmann, H E, Widen, E, Woodside, B, Yanovski, J, Yao, S, Zerwas, S, Zipfel, S, Thornton, L, Hinney, A, Daly, M, Sullivan, P F, Zeggini, E, Breen, G & Bulik, C M 2017, ' Significant locus and metabolic genetic correlations revealed in genome-wide association study of anorexia nervosa ', American Journal of Psychiatry, vol. 174, no. 9, pp. 850-858 . https://doi.org/10.1176/appi.ajp.2017.16121402
American Journal of Psychiatry, 174(9), 850. American Psychiatric Association
American Journal of Psychiatry, 174(9), 850-858. AMER PSYCHIATRIC PUBLISHING, INC
Am. J. Psychiatry 174, 850-858 (2017)
Dipòsit Digital de la UB
Universidad de Barcelona
ISSN: 0002-953X
Popis: Objective: The authors conducted a genome-wide association study of anorexia nervosa and calculated genetic correlations with a series of psychiatric, educational, and metabolic phenotypes. Method: Following uniformquality control and imputation procedures using the 1000 Genomes Project (phase 3) in 12 case-control cohorts comprising 3, 495 anorexia nervosa cases and 10, 982 controls, the authors performed standard association analysis followed by a meta-analysis across cohorts. Linkage disequilibrium score regression was used to calculate genome-wide common variant heritability (single-nucleotide polymorphism [SNP]-based heritability [h2 SNP]), partitioned heritability, and genetic correlations (rg) between anorexia nervosa and 159 other phenotypes. Results: Results were obtained for 10, 641, 224 SNPs and insertion-deletion variants with minor allele frequencies.>1% and imputation quality scores >0.6. The h2 SNP of anorexia nervosa was 0.20 (SE=0.02), suggesting that a substantial fraction of the twin-based heritability arises from common genetic variation. The authors identified one genome-wide significant locus on chromosome 12 (rs4622308) in a region harboring a previously reported type 1 diabetes and autoimmune disorder locus. Significant positive genetic correlations were observed between anorexia nervosa and schizophrenia, neuroticism, educational attainment, and high-density lipoprotein cholesterol, and significant negative genetic correlations were observed between anorexia nervosa and body mass index, insulin, glucose, and lipid phenotypes. Conclusions: Anorexia nervosa is a complex heritable phenotype for which this study has uncovered the first genomewide significant locus. Anorexia nervosa also has large and significant genetic correlations with both psychiatric phenotypes and metabolic traits. The study results encourage a reconceptualization of this frequently lethal disorder as one with both psychiatric and metabolic etiology.
Databáze: OpenAIRE
Externí odkaz: