Generalized principles of stochasticity can be used to control dynamic heterogeneity
| Autor: | David Liao, Luis Estévez-Salmerón, Thea D. Tlsty |
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| Rok vydání: | 2012 |
| Předmět: |
Proteome
Receptor ErbB-2 Biophysics Biology Cellular level Models Biological Article ErbB-2 Engineering Models Structural Biology Neoplasms Animals Humans Neoplasm Metastasis Control (linguistics) Molecular Biology Stochastic Processes Behavior Neoplastic Behavior Animal Ants Animal Ecology Stochastic process Oncogenes Cell Biology Biological Sciences Biological Variety (cybernetics) Gene Expression Regulation Neoplastic Multicellular organism Phenotype Gene Expression Regulation Biofilms Physical Sciences Cryptococcus neoformans Biological system Receptor |
| Zdroj: | Physical biology, vol 9, iss 6 Liao, D; Estévez-Salmerón, L; & Tlsty, TD. (2012). Generalized principles of stochasticity can be used to control dynamic heterogeneity. Physical Biology, 9(6). doi: 10.1088/1478-3975/9/6/065006. UCSF: Retrieved from: http://www.escholarship.org/uc/item/1qf2g8t3 |
| ISSN: | 1478-3975 1478-3967 |
| DOI: | 10.1088/1478-3975/9/6/065006 |
| Popis: | It is increasingly appreciated that phenotypic stochasticity plays fundamental roles in biological systems at the cellular level and that a variety of mechanisms generates phenotypic interconversion over a broad range of time scales. The ensuing dynamic heterogeneity can be used to understand biological and clinical processes involving diverse phenotypes in different cell populations. The same principles can be applied, not only to populations composed of cells, but also to populations composed of molecules, tissues, and multicellular organisms. Stochastic units generating dynamic heterogeneity can be integrated across various length scales. We propose that a graphical tool we have developed, called a metronomogram, will allow us to identify factors that suitably influence the restoration of homeostatic heterogeneity so as to modulate the consequences of dynamic heterogeneity for desired outcomes. © 2012 IOP Publishing Ltd. |
| Databáze: | OpenAIRE |
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