| Autor: |
Mahajan, Gautam, Doherty, Erin, To, Tania, Sutherland, Arlene, Grant, Jennifer, Junaid, Abidemi, Gulati, Aakanksha, LoGrande, Nina, Izadifar, Zohreh, Timilsina, Sanjay Sharma, Horváth, Viktor, Plebani, Roberto, France, Michael, Hood-Pishchany, Indriati, Rakoff-Nahoum, Seth, Kwon, Douglas S., Goyal, Girija, Prantil-Baun, Rachelle, Ravel, Jacques, Ingber, Donald E. |
| Rok vydání: |
2022 |
| DOI: |
10.6084/m9.figshare.21628684.v1 |
| Popis: |
Additional file 1: Supplementary Figure S1. Computational Model of Oxygen Gradient Generated by Vagina Chip. COMSOL 2D model with geometry adapted from the commercial Organ Chip (from Emulate Inc.) used in these studies. The chip contains two parallel channels under continuous flow with thick epithelial and fibroblast cell layers cultured respectively on the top and bottom of a 50 μm thick porous membrane that separates the two channels. Dotted arrows show sources of oxygen inflow and consumption in the chip. B) Surface plot demonstrating O2 distribution in the Vagina Chip. The lower graphs show results of O2 concentration simulations over time in apical epithelial channel (C) and basal fibroblast channel (D). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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