Rapid growth is a dominant predictor Of hepcidin suppression and declining ferritin in Gambian infants
| Autor: | Momodou K. Darboe, Bakary Darboe, Martin Antonio, Hal Drakesmith, Sant-Rayn Pasricha, George M. Weinstock, Schadrac C. Agbla, Andrew E. Armitage, Ebrima A. Sise, Modupeh Betts, Archibald Worwui, Andrew M. Prentice, Ellen Sambou, Momodou W. Jallow, Brenda Kwambana-Adams |
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| Rok vydání: | 2019 |
| Předmět: |
Anemia
Iron Physiology Iron metabolism & its Disorders Weight Gain Article 03 medical and health sciences 0302 clinical medicine Hepcidins Hepcidin hemic and lymphatic diseases Receptors Transferrin medicine Homeostasis Humans 030212 general & internal medicine Longitudinal Studies 030304 developmental biology Soluble transferrin receptor 2. Zero hunger chemistry.chemical_classification 0303 health sciences biology Anemia Iron-Deficiency business.industry Infant Newborn Transferrin Infant Hematology Iron deficiency medicine.disease Ferritin Malnutrition Cross-Sectional Studies chemistry Iron-deficiency anemia Ferritins biology.protein Gambia business |
| Zdroj: | Haematologica |
| ISSN: | 0390-6078 |
| Popis: | Iron deficiency and iron deficiency anemia are highly prevalent in low-income countries, especially among young children. Hepcidin is the major regulator of systemic iron homeostasis. It controls dietary iron absorption, dictates whether absorbed iron is made available in circulation for erythropoiesis and other iron-demanding processes, and predicts response to oral iron supplementation. Understanding how hepcidin is itself regulated is therefore important, especially in young children. We investigated how changes in iron-related parameters, inflammation and infection status, seasonality, and growth influenced plasma hepcidin and ferritin concentrations during infancy using longitudinal data from two birth cohorts of infants in rural Gambia (n=114 and n=193). This setting is characterized by extreme seasonality, prevalent childhood anemia, undernutrition, and frequent infection. Plasma was collected from infants at birth and at regular intervals, up to 12 months of age. Hepcidin, ferritin and plasma iron concentrations declined markedly during infancy, with reciprocal increases in soluble transferrin receptor and transferrin concentrations, indicating declining iron stores and increasing tissue iron demand. In cross-sectional analyses at 5 and 12 months of age, we identified expected relationships of hepcidin with iron and inflammatory markers, but also observed significant negative associations between hepcidin and antecedent weight gain. Correspondingly, longitudinal fixed effects modeling demonstrated weight gain to be the most notable dynamic predictor of decreasing hepcidin and ferritin through infancy across both cohorts. Infants who grow rapidly in this setting are at particular risk of depletion of iron stores, but since hepcidin concentrations decrease with weight gain, they may also be the most responsive to oral iron interventions. |
| Databáze: | OpenAIRE |
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