Choroidal neovascular membranes: treatment with reirradiation
| Autor: | Christopher Seery, A Abdelsalam, C S Cathcart, J N Halpern, Marco A. Zarbin |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Visual acuity medicine.medical_treatment Eye disease Visual Acuity Neovascularization Recurrence medicine Humans Radiology Nuclear Medicine and imaging Fluorescein Angiography Aged Aged 80 and over medicine.diagnostic_test Neovascularization Pathologic business.industry Choroid Dose fractionation Choroid Diseases Middle Aged medicine.disease Fluorescein angiography Surgery Radiation therapy medicine.anatomical_structure Angiography Retreatment Female Dose Fractionation Radiation medicine.symptom business Follow-Up Studies |
| Zdroj: | Radiology. 208(2) |
| ISSN: | 0033-8419 |
| Popis: | To evaluate re-treatment with an additional course of low-dose irradiation in patients with progressive or recurrent choroidal neovascular membranes (CNVMs).Ten patients who had received 14 Gy of external-beam radiation therapy in seven fractions for subfoveal CNVMs were found to have recurrent or persistent neovascularization at follow-up. They received an additional 15 Gy of radiation therapy administered in five daily fractions with a standard lens-sparing technique. Before reirradiation, visual acuity ranged from 20/80 to counting fingers. The median time between radiation courses was 6.5 months (range, 2-16 months). After re-treatment, the patients were followed up with angiography and visual field testing. The median follow-up was 18.5 months (range, 12-21 months).Eight of 10 patients (80%) maintained their visual acuity at 1 year and three of seven (43%) at 18 months. Visual acuity was stabilized in five of the 10 patients at their last follow-up. No acute or late side effects of irradiation were noted.Additional radiation therapy in selected patients with CNVMs who have failed to benefit from previous irradiation is well tolerated and appears to stabilize the disease process in a substantial proportion of these patients. |
| Databáze: | OpenAIRE |
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