Prevalence and spread of extended-spectrum β-lactamase-producing Enterobacteriaceae in Europe
| Autor: | Fernando Baquero, Rafael Cantón, Teresa M. Coque, Aránzazu Valverde, A. Novais, Elisabete Machado, Luísa Peixe |
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| Rok vydání: | 2008 |
| Předmět: |
Microbiology (medical)
Klebsiella pneumoniae review Drug resistance extended spectrum β-lactamases medicine.disease_cause beta-Lactamases Microbiology Plasmid Enterobacteriaceae Drug Resistance Multiple Bacterial Prevalence polycyclic compounds medicine Humans Escherichia coli Cross Infection Nosocomial outbreak biology Enterobacteriaceae Infections General Medicine biochemical phenomena metabolism and nutrition bacterial infections and mycoses biology.organism_classification Community-Acquired Infections Europe Infectious Diseases Carrier State DNA Transposable Elements epidemiology Mobile genetic elements CTX-M enzymes Bacteria Plasmids |
| Zdroj: | Clinical Microbiology and Infection. 14:144-153 |
| ISSN: | 1198-743X |
| DOI: | 10.1111/j.1469-0691.2007.01850.x |
| Popis: | Extended-spectrum β-lactamases (ESBLs) represent a major threat among resistant bacterial isolates. The first types described were derivatives of the TEM-1, TEM-2 and SHV-1 enzymes during the 1980s in Europe, mainly in Klebsiella pneumoniae associated with nosocomial outbreaks. Nowadays, they are mostly found among Escherichia coli isolates in community-acquired infections, with an increasing occurrence of CTX-M enzymes. The prevalence of ESBLs in Europe is higher than in the USA but lower than in Asia and South America. However, important differences among European countries have been observed. Spread of mobile genetic elements, mainly epidemic plasmids, and the dispersion of specific clones have been responsible for the increase in ESBL-producing isolates, such as those with TEM-4, TEM-24, TEM-52, SHV-12, CTX-M-9, CTX-M-14, CTX-M-3, CTX-M-15 and CTX-M-32 enzymes. |
| Databáze: | OpenAIRE |
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