Unraveling the etiology of ovarian cancer racial disparity in the deep south: Is it nature or nurture?
| Autor: | Megan Missanelli, Alex Cohen, Ajay P. Singh, Mary Danner Harmon, Katelyn V. Braswell, Luciana Madeira da Silva, Michael A. Finan, J.G. Ross, Jennifer Scalici, Rodney P. Rocconi, William Nicolson, Sam Stutsman, Frances Currin Mujica |
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| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Racial disparity Optimal Debulking Black People Disease Carcinoma Ovarian Epithelial Disease-Free Survival White People Nature versus nurture Cohort Studies 03 medical and health sciences 0302 clinical medicine medicine Humans Neoplasms Glandular and Epithelial 030212 general & internal medicine Socioeconomic status Neoplasm Staging Retrospective Studies Ovarian Neoplasms Gynecology business.industry Obstetrics and Gynecology Retrospective cohort study Health Status Disparities Middle Aged medicine.disease Socioeconomic Factors Oncology 030220 oncology & carcinogenesis Alabama Etiology Female Ovarian cancer business Demography |
| Zdroj: | Gynecologic Oncology. 145:329-333 |
| ISSN: | 0090-8258 |
| DOI: | 10.1016/j.ygyno.2017.02.025 |
| Popis: | Our objective was to evaluate racial treatment and survival disparities in black women with ovarian cancer in the Deep South and to determine how environmental factors / socioeconomic status (SES) influence survival.A retrospective study of ovarian cancer patients from 2007 to 2014 was performed. Socioeconomic status (SES) was obtained though U.S. Census block data and compared using Yost scores. Comparisons were performed using standard statistical approaches.A total of 393 patients were evaluated, 325 (83%) white and 68 (17%) black. Demographic information and surgical approach were similar in each racial group. However, compared to whites, black patients had lower rates of optimal debulking [89% vs. 71%, respectively (p=0.001)] and intraperitoneal chemotherapy (19% vs. 11%, p=0.01). Black women had lower SES parameters including education, income, and poverty. As a result, more black patients had the lowest SES (SES-1) when compared to white patients (17% vs. 41%, p0.001). When controlling for these factors by cox regression analysis, a survival disadvantage was seen in black women for both progression free survival (16 vs. 27months, p=0.003) and overall survival (42 vs. 88months, p0.001).Despite controlling for clinical and environmental factors, a survival disadvantage was still observed in black patients with ovarian cancer in the Deep South. Black women had lower optimal debulking rates and more platinum resistant disease. These data suggest other factors like tumor biology may play a role in racial survival differences, however, more research is needed to determine this causation. |
| Databáze: | OpenAIRE |
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