Bone mineral: new insights into its chemical composition
| Autor: | Guillaume Laurent, Stanislas Von Euw, Thierry Azaïs, Christophe Drouet, Nadine Nassif, Yan Wang, Florence Babonneau |
|---|---|
| Přispěvatelé: | Spectroscopie, Modélisation, Interfaces pour L'Environnement et la Santé (LCMCP-SMiLES), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Trinity Centre for Bioengineering [Dublin] (TCBE), Trinity Biomedical Sciences Institute [Dublin], Trinity College Dublin-Trinity College Dublin, Centre interuniversitaire de recherche et d'ingenierie des matériaux (CIRIMAT), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC), Matériaux Hybrides et Procédés (LCMCP-MHP ), Matériaux Hybrides et Nanomatériaux (LCMCP-MHN), Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), ANR-09-BLAN-0120,NANOSHAP,Hydroxyapatites substituées nanocristallisées et leurs interfaces avec les milieux biologiques(2009), Centre National de la Recherche Scientifique - CNRS (FRANCE), Collège de France (FRANCE), Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE), Sorbonne Université (FRANCE), Université Toulouse III - Paul Sabatier - UT3 (FRANCE), Institut National Polytechnique de Toulouse - INPT (FRANCE) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Biomineralization Calcium Phosphates Mature Bone Magnetic Resonance Spectroscopy Bone density Matériaux lcsh:Medicine Bone tissue Solid-state NMR Article Bone and Bones 03 medical and health sciences 0302 clinical medicine Calcification Physiologic Bone Density Spectroscopy Fourier Transform Infrared medicine Animals Humans Bone mineral [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology Amorphous calcium phosphate lcsh:Science [SDV.IB.BIO]Life Sciences [q-bio]/Bioengineering/Biomaterials Chemical composition Ions Multidisciplinary Sheep Chemistry lcsh:R Magnetic Resonance Imaging Amorphous solid 030104 developmental biology medicine.anatomical_structure Durapatite Chemical engineering lcsh:Q Calcium 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports Scientific Reports, Nature Publishing Group, 2019, 9, pp.8456. ⟨10.1038/s41598-019-44620-6⟩ Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019) |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-019-44620-6⟩ |
| Popis: | Some compositional and structural features of mature bone mineral particles remain unclear. They have been described as calcium-deficient and hydroxyl-deficient carbonated hydroxyapatite particles in which a fraction of the PO43− lattice sites are occupied by HPO42− ions. The time has come to revise this description since it has now been proven that the surface of mature bone mineral particles is not in the form of hydroxyapatite but rather in the form of hydrated amorphous calcium phosphate. Using a combination of dedicated solid-state nuclear magnetic resonance techniques, the hydrogen-bearing species present in bone mineral and especially the HPO42− ions were closely scrutinized. We show that these HPO42− ions are concentrated at the surface of bone mineral particles in the so-called amorphous surface layer whose thickness was estimated here to be about 0.8 nm for a 4-nm thick particle. We also show that their molar proportion is much higher than previously estimated since they stand for about half of the overall amount of inorganic phosphate ions that compose bone mineral. As such, the mineral-mineral and mineral-biomolecule interfaces in bone tissue must be driven by metastable hydrated amorphous environments rich in HPO42− ions rather than by stable crystalline environments of hydroxyapatite structure. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|