Exploratory factor analysis of obsessive-compulsive patients and association with 5-HTTLPR polymorphism
| Autor: | Francesca Malchiodi, Maria Cristina Cavallini, Laura Bellodi, Daniela Di Bella, Francesca Siliprandi |
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| Přispěvatelé: | Cavallini, Mc, Di Bella, D, Siliprandi, F, Malchiodi, F, Bellodi, Laura |
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Obsessive-Compulsive Disorder Adolescent Genotype Poison control Nerve Tissue Proteins Genetic determinism Gene Frequency mental disorders medicine Humans Promoter Regions Genetic Genetics (clinical) Serotonin transporter Alleles Aged Genetics Serotonin Plasma Membrane Transport Proteins Analysis of Variance Membrane Glycoproteins Polymorphism Genetic biology Membrane Transport Proteins DNA Middle Aged medicine.disease humanities Aggression 5-HTTLPR biology.protein Etiology Female Obsessive Behavior Carrier Proteins Anxiety disorder Psychopathology |
| Zdroj: | American journal of medical genetics. 114(3) |
| ISSN: | 0148-7299 |
| Popis: | The determination of a genetic basis for obsessive-compulsive disorder (OCD) depends on how phenotypic boundaries are defined. Although a hypothesis for serotonin dysfunction in OCD has been advanced, no genes specifically responsible for serotonin regulation have as yet been definitively related to the etiology of OCD. The phenotypic variability of OCD could be at the basis of the failure of molecular biology investigations to find any genes involved in the liability to the disorder. Obsessive and compulsive contents can aggregate in OCD patients differently, multifactorial description may therefore be able to account for OCD phenotypic variance. Using principal component analysis, we derived five factors from 13 main contents of the Yale-Brown Obsessive-Compulsive Scale (YBOCS), and considered them as quantitative phenotypes to evaluate their possible association with an insertion/deletion polymorphisin in the promoter region of the serotonin transporter gene (5-HTTLPR). A trend toward positive association between the fifth factor, including counting and repeating rituals, and 5-HTTLPR was found. However, only considering the subgroup of patients with tic codiagnosis, we found a significantly higher score for the fifth factor for patients with L/L genotype with respect to L/S and S/S genotypes. (C) 2002 Wiley-Liss, Inc. ZR 0 Z8 1 ZS 3 ZB 56 |
| Databáze: | OpenAIRE |
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