Drug delivery applications of poly-γ-glutamic acid
| Autor: | Olubusola A. Odeniyi, Michael Ayodele Odeniyi, Olalekan A. Balogun-Agbaje |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification Poly-γ-glutamic acid Medium optimization 030106 microbiology Nanoparticle Nanotechnology Polymer Glutamic acid RM1-950 Biodegradation engineering.material Biocompatible material Action sites RS1-441 03 medical and health sciences 030104 developmental biology Pharmacy and materia medica chemistry Drug delivery engineering Nanoparticles Biopolymer Therapeutics. Pharmacology |
| Zdroj: | Future Journal of Pharmaceutical Sciences, Vol 7, Iss 1, Pp 1-10 (2021) |
| ISSN: | 2314-7253 |
| Popis: | Background Poly-γ-glutamic acid (γ-PGA) is a biopolymer of microbial origin, consisting of repeating units of l-glutamic acid and/or D-glutamic acid. The biopolymer has found use in the fields of agriculture, food, wastewater, and medicine, owing to its non-toxic, biodegradable, and biocompatible properties. Due to its biodegradability, γ-PGA is being tipped to dislodge synthetic plastics in drug delivery application. High cost of production, relative to plastics, is however a clog in the wheel of achieving this. Main body of abstract This review looked at the production, nanoparticles fabrication, and drug delivery application of γ-PGA. γ-PGA production optimization by modifying the fermentation medium to tailor towards the production of desirable polymer at reduced cost and techniques for the formulation of γ-PGA nanoparticle as well as its characterization were discussed. This review also evaluated the application of γ-PGA and its nanoparticles in the delivery of drugs to action site. Characterization of γ-PGA and its nanoparticles is a crucial step towards determining the applicability of the biopolymer. γ-PGA has been used in the delivery of active agents to action sites. Conclusion This review highlights some of the efforts that have been made in the appraisal of γ-PGA and its nanoparticles for drug delivery. γ-PGA is a candidate for future extensive use in drug delivery. |
| Databáze: | OpenAIRE |
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