Increasing Serotonin to Reduce Parkinsonian Tremor
| Autor: | Adriano Capirchio, Daniele Caligiore, Silvia Buscaglione, Francesco Montedori |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Cognitive Neuroscience Parkinson's disease Neuroscience (miscellaneous) Neurosciences. Biological psychiatry. Neuropsychiatry tremor alternative treatment Serotonergic Pharmacological treatment Parkinson's disease early diagnosis 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Developmental Neuroscience Dopamine Medicine Resting tremor system-level neuroscience Original Research Computational neuroscience business.industry system neuroscience serotonin 030104 developmental biology serotonin and dopamine interplay different parkinsonian tremor types computational models new therapy for Parkinsonian tremor differential equations brain modeling patient digital twin Serotonin business Neuroscience 030217 neurology & neurosurgery medicine.drug computational neuroscience RC321-571 |
| Zdroj: | Frontiers in Systems Neuroscience, Vol 15 (2021) Frontiers in systems neuroscience 15 (2021). doi:10.3389/fnsys.2021.682990 info:cnr-pdr/source/autori:Caligiore D.; Montedori F.; Buscaglione S.; Capirchio A./titolo:Increasing Serotonin to Reduce Parkinsonian Tremor/doi:10.3389%2Ffnsys.2021.682990/rivista:Frontiers in systems neuroscience/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:15 Frontiers in Systems Neuroscience |
| ISSN: | 1662-5137 |
| DOI: | 10.3389/fnsys.2021.682990/full |
| Popis: | While current dopamine-based drugs seem to be effective for most Parkinson's disease (PD) motor dysfunctions, they produce variable responsiveness for resting tremor. This lack of consistency could be explained by considering recent evidence suggesting that PD resting tremor can be divided into different partially overlapping phenotypes based on the dopamine response. These phenotypes may be associated with different pathophysiological mechanisms produced by a cortical-subcortical network involving even non-dopaminergic areas traditionally not directly related to PD. In this study, we propose a bio-constrained computational model to study the neural mechanisms underlying a possible type of PD tremor: the one mainly involving the serotoninergic system. The simulations run with the model demonstrate that a physiological serotonin increase can partially recover dopamine levels at the early stages of the disease before the manifestation of overt tremor. This result suggests that monitoring serotonin concentration changes could be critical for early diagnosis. The simulations also show the effectiveness of a new pharmacological treatment for tremor that acts on serotonin to recover dopamine levels. This latter result has been validated by reproducing existing data collected with human patients. |
| Databáze: | OpenAIRE |
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