Distinct molecular patterns based on proximal and distal sporadic colorectal cancer: arguments for different mechanisms in the tumorigenesis
| Autor: | Luigi Roncoroni, Giovanni Bader, Davide Di Mauro, Cinzia Azzoni, Gabriella Di Cola, Lorena Bottarelli, Carlo Salvemini, Cesare Bordi, Enrico Donadei, Silvia Morari, Antonio Mazzeo, Leopoldo Sarli, Nicoletta Campanini |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Pathology medicine.medical_specialty Colorectal cancer Loss of Heterozygosity medicine.disease_cause Loss of heterozygosity FHIT Proliferating Cell Nuclear Antigen Biomarkers Tumor Humans Medicine neoplasms Adaptor Proteins Signal Transducing Aged Splenic flexure business.industry Gastroenterology Nuclear Proteins Microsatellite instability Cancer medicine.disease Immunohistochemistry Survival Analysis digestive system diseases Acid Anhydride Hydrolases Neoplasm Proteins Cell Transformation Neoplastic MutS Homolog 2 Protein Cyclooxygenase 2 Female Microsatellite Instability Colorectal Neoplasms MutL Protein Homolog 1 business Carcinogenesis |
| Zdroj: | International Journal of Colorectal Disease. 22:115-126 |
| ISSN: | 1432-1262 0179-1958 |
| DOI: | 10.1007/s00384-006-0093-x |
| Popis: | Colorectal cancer (CRC) ranks as the fourth most frequently diagnosed cancer worldwide. CRCs that arise proximally or distally to the splenic flexure show differences in epidemiologic incidence, morphology, and molecular alterations, suggesting the existence of two categories of CRC based on the site of origin. The aim of the present work is to investigate the histological and molecular differences between CRCs located proximally and distally to the splenic flexure, and their potential involvement in tumor prognosis and therapeutic strategies. We evaluated 120 patients affected by sporadic CRC for clinicopathologic features, microsatellite instability (MSI), loss of heterozygosity (LOH) of chromosomes 18q, 8p, and 4p; they were also investigated for hMlh1, hMsh2, Fhit, p27, and Cox-2 immunostaining. The mucinous histotype was more frequent in the proximal than in the distal CRCs (p |
| Databáze: | OpenAIRE |
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