Eimeria tenella, E. necatrix, E. acervulina, E. maxima, and E. brunetti: potent anticoccidial activity of an uridine analog, 1-(beta-D-ribofuranosyl)-2(1H)-pyrazinone 4-oxide
| Autor: | Toshiyuki Yamazaki, Kin-Ichi Imai, Toshio Ishii, Toshimi Matsuno, Fumio Hariguchi, Nobuo Kobayashi, Hiroshi Onaga |
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| Rok vydání: | 1986 |
| Předmět: |
Male
Immunology Biology Eimeria brunetti Eimeria Schizogony chemistry.chemical_compound Eimeria necatrix Species Specificity parasitic diseases Animals Poultry Diseases Coccidiosis Body Weight Biological activity General Medicine biology.organism_classification Animal Feed Uridine Eimeria acervulina Infectious Diseases Biochemistry chemistry Eimeria maxima Coccidiostats Parasitology Ribonucleosides Chickens |
| Zdroj: | Experimental parasitology. 61(1) |
| ISSN: | 0014-4894 |
| Popis: | The anticoccidial activity of an uridine analog, 1-(β- d -ribofuranosyl)-2(1 H )-pyrazinone 4-oxide (emimycin riboside), against five species of chicken Eimeria was tested individually in battery experiments. With 16 ppm of the compound in feed, marked anticoccidial activity was obtained against Eimeria tenella , E. necatrix, E. acervulina, E. maxima, and E. brunetti . The last named species was more drug-sensitive than the others—dietary levels of at least 8 ppm of the drug exhibited good protection and eliminated practically all clinical signs. The battery tests with delayed and restricted medications showed that emimycin riboside affected the development of parasites in first and second generation schizogony of the life cycle of E. tenella . |
| Databáze: | OpenAIRE |
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