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Shang Lin,1 Ya-ru Wei,2 Hong-xiang Yao3 1Department of Nuclear Medicine, The Second Affiliated Hospital and Yuying Childrenâs Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325002, Peopleâs Republic of China; 2Department of Radiology, The Second Affiliated Hospital and Yuying Childrenâs Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325002, Peopleâs Republic of China; 3Department of Interventional Radiology, The Second Affiliated Hospital and Yuying Childrenâs Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325002, Peopleâs Republic of ChinaCorrespondence: Hong-xiang YaoDepartment of Interventional Radiology, The Second Affiliated Hospital and Yuying Childrenâs Hospital of Wenzhou Medical University, 109 Xueyuan Western Road, Wenzhou, 325002, Zhejiang, Peopleâs Republic of ChinaEmail lsyhx2004@163.comBackground: Hundreds of studies have reported the application of iodine-131 (I-131) in thyroid carcinoma (THCA) in past years. However, the status of research in the field and other related topics have not been investigated. This study aimed to identify the cooperation of authors, countries, and institutions, as well as explore the hot topics and prospects regarding I-131 therapy in THCA based on previous studies.Methods: Publications from 2010 to 2020 were retrieved from Web of Science Core Collection according to research strategy. Bibliometric analyses were performed using VOSviewer 1.6.15 and CiteSpace 5.7.3 to evaluate and visualize the cooperation network, hot topic, and research frontier.Results: The number of publications showed a trend of fluctuation between 2010 and 2020. We identified 1387 publications related to I-131 therapy in THCA, which were published by 1628 institutions from 82 countries. The largest proportion of publications were emanated from the USA, and the majority of papers were published by Thyroid. Shanghai Jiao Tong University of China contributed the most papers. Although many authors participated in the research of this field, high-yield authors were few. Co-occurrence analysis classified keywords into five clusters, including assessment, efficacy measurement, monitoring, hormone regulation, and guidelines of I-131 therapy. The terms âbone marrow dosimetry and timeâ were among the latest hotspots. The research frontier topic in I-131 therapy focused on the âP53 and anti-Müllerian hormoneâ.Conclusion: The attention to I-131 therapy in THCA should be increased considerably. It was necessary to construct active co-operations between authors, countries, and institutions to promote the development of this field. Recent researches referred to the timing and dose assessment of I-131 therapy in THCA. Future studies likely focused on targeted therapy and adverse effects evaluation were worthy of research as well.Keywords: I-131, thyroid carcinoma, bibliometric analysis, hot spots, research trend |