SAMHD1 and the innate immune response to cytosolic DNA during DNA replication
| Autor: | Christoph Neumayer, Yea-Lih Lin, Flavie Coquel, Philippe Pasero |
|---|---|
| Přispěvatelé: | Institut de génétique humaine (IGH), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2019 |
| Předmět: |
DNA Replication
0301 basic medicine Microbial DNA RNase P [SDV]Life Sciences [q-bio] Immunology Genotoxic Stress Biology Nervous System Malformations SAM Domain and HD Domain-Containing Protein 1 03 medical and health sciences chemistry.chemical_compound Autoimmune Diseases of the Nervous System Cytosol 0302 clinical medicine Immunity Animals Humans Immunology and Allergy DNA Breaks Double-Stranded Immunologic Surveillance [SDV.GEN]Life Sciences [q-bio]/Genetics Innate immune system DNA replication Membrane Proteins DNA Nucleotidyltransferases Immunity Innate 3. Good health Cell biology 030104 developmental biology chemistry 030215 immunology SAMHD1 |
| Zdroj: | Current Opinion in Immunology Current Opinion in Immunology, Elsevier, 2019, 56, pp.24-30. ⟨10.1016/j.coi.2018.09.017⟩ |
| ISSN: | 0952-7915 |
| DOI: | 10.1016/j.coi.2018.09.017 |
| Popis: | International audience; Cytosolic DNA of endogenous or exogenous origin is sensed by the cGAS-STING pathway to activate innate immune responses. Besides microbial DNA, this pathway detects self-DNA in the cytoplasm of damaged or abnormal cells and plays a central role in antitumor immunity. The mechanism by which cytosolic DNA accumulates under genotoxic stress conditions is currently unclear, but recent studies on factors mutated in the Aicardi-Goutières syndrome cells, such as SAMHD1, RNase H2 and TREX1, are shedding new light on this key process. In particular, these studies indicate that the rupture of micronuclei and the release of ssDNA fragments during the processing of stalled replication forks and chromosome breaks represent potent inducers of the cGAS-STING pathway. |
| Databáze: | OpenAIRE |
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